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Recent progress in tissue optical clearing [PDF]
Laser and Photonics Reviews, 2013 AbstractTissue optical clearing technique provides a prospective solution for the application of advanced optical methods in life sciences. This paper gives a review of recent developments in tissue optical clearing techniques. The physical, molecular and physiological mechanisms of tissue optical clearing are overviewed and discussed.
Dan Zhu, Kirill V Larin, Qingming Luo
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Nature, 1962
THE separation, isolation and identification of the protein fractions in different tissues have recently been of ever-increasing interest, because of the possibility of isolating biologically very active fractions, for example, serum protein fractions from placental tissue1 or fractions which influence the coagulation system2.
A, HANSEN, J, CLAUSEN, R, JENSEN
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THE separation, isolation and identification of the protein fractions in different tissues have recently been of ever-increasing interest, because of the possibility of isolating biologically very active fractions, for example, serum protein fractions from placental tissue1 or fractions which influence the coagulation system2.
A, HANSEN, J, CLAUSEN, R, JENSEN
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Tissue Clearing for Optical Anatomy
Angewandte Chemie International Edition, 2013Quest for transparency: Detailed optical imaging of complex biological entities remains an unmet goal mainly because of the light scattering of biological tissue. A new approach to tissue clearing termed CLARITY is getting us closer to an anatomical view of thick tissues and entire organs with cellular resolution.
Dmytro A, Yushchenko, Carsten, Schultz
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Tissue optical immersion clearing
Expert Review of Medical Devices, 2010In this article, we discuss the optical immersion method based on refractive index matching of scatterers (e.g., collagen, elastin fibers, cells and cell compartments) and the ground material (interstitial fluid and/or cytoplasm) of tissue and blood under the action of exogenous optical clearing agents.
Elina A, Genina +2 more
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Applications of tissue clearing in the spinal cord
European Journal of Neuroscience, 2020Abstract The locomotor networks in the spinal cord coordinate muscle contractions and govern limb movements, ensuring postural body stability and smooth locomotion at different speeds. Dissecting the organization and connection of spinal motor networks is crucial to interpret their functional roles and thus can help to design more ...
Ting Tian, Xiaoguang Li
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Liposome Imaging in Optically Cleared Tissues
Nano Letters, 2020Three-dimensional (3D) optical microscopy can be used to understand and improve the delivery of nanomedicine. However, this approach cannot be performed for analyzing liposomes in tissues because the processing step to make tissues transparent for imaging typically removes the lipids. Here, we developed a tag, termed REMNANT, that enables 3D imaging of
Abdullah Muhammad Syed +12 more
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Clearing Brain Tissue with Anethole
Stain Technology, 1948Groat (1941) called attention to the necessity of matching the refractive index of the tissue and clearer to obtain maximum transparency of in toto cleared specimens. Tissues that are refractively almost homogeneous, such as muscle, can be cleared after bleaching and dehydrating by placing in an oil of similar refractive index.
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Optical clearing for multiscale biological tissues
Journal of Biophotonics, 2017Three‐dimensional reconstruction of tissue structures is essential for biomedical research. The development of light microscopes and various fluorescent labeling techniques provides powerful tools for this motivation. However, optical imaging depth suffers from strong light scattering due to inherent heterogeneity of biological tissues.
Tingting Yu +4 more
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Clear Cell Tumors of Soft Tissue
Surgical Pathology Clinics, 2011Clear cell lesions of soft tissue include varying morphologic patterns and a range of clinical behaviors and prognoses. Benign lesions include perivascular epithelioid cell tumors, clear cell fibrous papule, and distinctive dermal clear cell mesenchymal tumor; malignant tumors include clear cell sarcoma, liposarcoma, and rare malignant perivascular ...
Aaron, Auerbach, David S, Cassarino
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Clear cell sarcoma of soft tissues
Journal of Surgical Oncology, 2006AbstractClear cell sarcoma (CCS) is a rare but highly malignant tumor of soft tissues often appearing as a small tender mass in the deep tissues of the distal extremities. We have studied 17 patients with such lesions treated since 1986 and have a high incidence of local recurrence and metastasis with a survival rate of only 47% despite surgery and for
Sara Sofia, Malchau +3 more
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