Results 61 to 70 of about 1,922,235 (275)

Magnetic resonance imaging study of diamagnetic and paramagnetic agents for optical clearing of tumor-specific fluorescent signal in vivo

, 2021
The potential of magnetic resonance imaging (MRI) pulse sequences for monitoring local changes in proton relaxation times after the local application of skin optical clearing (OC) compositions in vivo has so far remained largely unexplored.
Alexei A. Bogdanov, Alexander P. Savitsky, Bogdanov, Alexei A. Jr., Meerovich, Irina G., Valery V. Tuchin, Natalia I. Kazachkina, Tuchina, Daria K., Victoria V. Zherdeva, Kazachkina, Natalia I., Solovyev, Ilya D., Savitsky, Alexander P., Daria K. Tuchina, Irina G. Meerovich, Zherdeva, Victoria V., Tuchin, Valery V., Ilya D. Solovyev   +15 more
core   +1 more source

On-slide clearing and imaging of 100-µm-thick histological sections using ethyl cinnamate and epifluorescence [PDF]

Folia Medica
Introduction: Thick histological samples are difficult to image without proper tissue clearing methods. Among these methods ethyl cinnamate (ECi)-based clearing preserves antigenicity and is compatible with immunofluorescent labeling. In contrast to many
Andreas Kontny, Dimo Stoyanov, Pavel Pavlov, Neele Wagner, Nikola Kolev, Alexander Zlatarov, Turgay Kalinov, Anton B. Tonchev   +7 more
doaj   +3 more sources

Biomedical Applications of Tissue Clearing and Three-Dimensional Imaging in Health and Disease

iScience, 2020
Summary: Three-dimensional (3D) optical imaging techniques can expand our knowledge about physiological and pathological processes that cannot be fully understood with 2D approaches.
Maria Victoria Gómez-Gaviro, Daniel Sanderson, Jorge Ripoll, Manuel Desco   +3 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Tutorial: practical considerations for tissue clearing and imaging

, 2021
Tissue clearing has become a powerful technique for studying anatomy and morphology at scales ranging from entire organisms to subcellular features. With the recent proliferation of tissue-clearing methods and imaging options, it can be challenging to ...
Shepherd, Douglas P., Weiss, Kurt R., Voigt, Fabian F., Huisken, Jan   +3 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Optical clearing: impact of optical and dielectric properties of clearing solutions on pulmonary tissue mechanics

, 2017
Optical clearing allows tissue visualization under preservation of organ integrity. Optical clearing of organs with a physiological change in three-dimensional geometry (such as the lung) would additionally allow visualization of macroscopic and ...
Runck, Hanna, Hans-Joachim Priebe, Schneider, Matthias, Schwenninger, David, Matthias Schneider, David Schwenninger, Hanna Runck, Josef Guttmann, Guttmann, Joseph, Priebe, Hans-Joachim   +9 more
core   +1 more source

Dehydration mechanism of optical clearing in tissue

Journal of Biomedical Optics, 2006
Previous studies identified various mechanisms of light scattering reduction in tissue induced by chemical agents. Our results suggest that dehydration is an important mechanism of optical clearing in collagenous and cellular tissue. Photographic and optical coherence tomography images indicate that air-immersed skin and tendon specimens become ...
Christopher G, Rylander, Oliver F, Stumpp, Thomas E, Milner, Nate J, Kemp, John M, Mendenhall, Kenneth R, Diller, A J, Welch   +6 more
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source