Results 91 to 100 of about 2,261,601 (352)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Comparison between traditional and digital anterior repositioning splints on the upper airway in skeletal class II malocclusion with TMJ degenerative disease

Scientific Reports
This retrospective observational study compared the effects of traditional Anterior Repositioning Splint (ARS) and digital ARS on the upper airway of patients with skeletal Class II malocclusion and temporomandibular joint degenerative joint disease.
Shufang Luo, Lei Xu, Yaqun Deng, Yaxin Zheng, Qianju Wu, Zhisheng Zhang, Jinyi He, Erle Lin   +7 more
doaj   +1 more source

Capillary hemangioma of tympanic cleft [PDF]

, 2009
We present an extensive capillary hemangioma of right ear in an 11-year-old child involving external auditory canal, middle ear and mastoid. Patient was presented with chronic purulent discharge and aural mass in right ear. The Computarize tomography (CT)
Bhandary, Sangita, Karki, Smirti, Singh, Rakesh Kumar, Tiwary, Awadhesh   +3 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Probenecid relieves LPS-induced neuroinflammation by modulating the NLRP1 inflammasome pathway in BV2 cells

Scientific Reports
Inflammation is a key factor in neurodegenerative diseases (NDs) development, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Microglial cells maintain immune microenvironment homeostasis in the central nervous system (CNS) and are ...
Xiaoxuan Wang, Haozhe Tian, Shifei Chen, Liangliang Ying, Juan Zheng, Yaya Song, Jin Xi, Yuxin Zhang, Dong Wang   +8 more
doaj   +1 more source

Culture of periprosthetic tissue in blood culture bottles for diagnosing periprosthetic joint infection [PDF]

, 2019
Background: The purpose of this meta-analysis was to evaluate the diagnostic accuracy of periprosthetic tissue culture in blood culture bottles (BCB) for periprosthetic joint infection (PJI).
Li, Cheng, Ojeda-Thies, Cristina, Trampuz, Andrej   +2 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Exploring the feasibility of AI-based analysis of histopathological variability in salivary gland tumours

Scientific Reports
This study uses artificial intelligence (AI) for differentiation between salivary gland tumours (SGT) using digitised Haematoxylin and Eosin stained whole-slide images (WSI).
Ibrahim Alsanie, Adam Shephard, Neda Azarmehr, Pablo Vargas, Miranda Pring, Nasir M. Rajpoot, Syed Ali Khurram   +6 more
doaj   +1 more source

Prediction of final infarct volume from native CT perfusion and treatment parameters using deep learning [PDF]

, 2019
CT Perfusion (CTP) imaging has gained importance in the diagnosis of acute stroke. Conventional perfusion analysis performs a deconvolution of the measurements and thresholds the perfusion parameters to determine the tissue status.
Boers, Anna M. M., Dippel, Diederik W. J., Langezaal, Lucianne L. C. M., Lemmens, Robin, Majoie, Charles B. L. M., Marquering, Henk A., Robben, David, Roos, Yvo B. W. E. M., Suetens, Paul, van der Lugt, Aad, van Oostenbrugge, Robert J., van Zwam, Wim H.   +11 more
core   +3 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source