Results 71 to 80 of about 1,553,407 (312)

Intervertebral disc degeneration in dogs [PDF]

, 2010
Back pain is common in both dogs and humans, and is often associated with intervertebral disc (IVD) degeneration. The IVDs are essential structures of the spine and degeneration can ultimately result in diseases such as IVD herniation or spinal ...
Bergknut, Niklas, Tissue Repair, Bergknut, N., Geneeskunde van gezelschapsdieren   +3 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Preoperative tissue diagnosis for tumours of the pancreas

Journal of British Surgery, 2009
Abstract Background Preoperative biopsy of pancreatic lesions suspected of malignancy is controversial. Methods A systematic Medline literature search was carried out.
W, Hartwig, L, Schneider, M K, Diener, F, Bergmann, M W, Büchler, J, Werner   +5 more
openaire   +2 more sources

Validation and clinical application of molecular methods for the identification of molds in tissue

, 2006
Background. Invasive fungal infections due to less-common molds are an increasing problem, and accurate diagnosis is difficult.Methods. We used our previously established molecular method, which allows species identification of molds in histological ...
Potter, M, Paterson, PJ, McLaughlin, J, Prentice, HG, McHugh, TD, Kibbler, CC, Seaton, S   +6 more
core  

Applications of Raman spectroscopy to urology [PDF]

, 2006
Raman spectroscopy is an optical technique that can interrogate biological tissues. In doing so it gives us an understanding of the changes in the molecular structure that are associated with disease development.
Hart Prieto, Maria Consuelo
core  

Designing heterogeneous porous tissue scaffolds for additive manufacturing processes [PDF]

, 2013
A novel tissue scaffold design technique has been proposed with controllable heterogeneous architecture design suitable for additive manufacturing processes.
Khoda, AKM Bashirul, Koç, Bahattin, Özbolat, İbrahim T.   +2 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Comparison between traditional and digital anterior repositioning splints on the upper airway in skeletal class II malocclusion with TMJ degenerative disease

Scientific Reports
This retrospective observational study compared the effects of traditional Anterior Repositioning Splint (ARS) and digital ARS on the upper airway of patients with skeletal Class II malocclusion and temporomandibular joint degenerative joint disease.
Shufang Luo, Lei Xu, Yaqun Deng, Yaxin Zheng, Qianju Wu, Zhisheng Zhang, Jinyi He, Erle Lin   +7 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Probenecid relieves LPS-induced neuroinflammation by modulating the NLRP1 inflammasome pathway in BV2 cells

Scientific Reports
Inflammation is a key factor in neurodegenerative diseases (NDs) development, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Microglial cells maintain immune microenvironment homeostasis in the central nervous system (CNS) and are ...
Xiaoxuan Wang, Haozhe Tian, Shifei Chen, Liangliang Ying, Juan Zheng, Yaya Song, Jin Xi, Yuxin Zhang, Dong Wang   +8 more
doaj   +1 more source