Results 61 to 70 of about 5,346,855 (293)

Automated Discrimination of Pathological Regions in Tissue Images: Unsupervised Clustering vs Supervised SVM Classification [PDF]

, 2008
Recognizing and isolating cancerous cells from non pathological tissue areas (e.g. connective stroma) is crucial for fast and objective immunohistochemical analysis of tissue images.
Enrico Macii, Elisa Ficarra, Santa Di Cataldo, Ficarra, Elisa, Di Cataldo, Santa, Macii, Enrico   +5 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

An explainable predictive machine learning model of osteopenia for perimenopausal women based on clinical data: a retrospective single-center study

Frontiers in Endocrinology
BackgroundOsteoporosis is increasingly prevalent, yet early detection remains difficult. This study aimed to develop a machine learning (ML)-based model for identifying individuals at risk of osteopenia using clinical data.MethodsFemale participants who ...
Xiaoling Zhuo, Xiaoling Zhuo, Huixian Zeng, Huoqiang Chen, Huoqiang Chen, Yunlin Wang, Zhenhua Feng, Zhenhua Feng, Quanhui Liang, Quanhui Liang   +9 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Comparison between traditional and digital anterior repositioning splints on the upper airway in skeletal class II malocclusion with TMJ degenerative disease

Scientific Reports
This retrospective observational study compared the effects of traditional Anterior Repositioning Splint (ARS) and digital ARS on the upper airway of patients with skeletal Class II malocclusion and temporomandibular joint degenerative joint disease.
Shufang Luo, Lei Xu, Yaqun Deng, Yaxin Zheng, Qianju Wu, Zhisheng Zhang, Jinyi He, Erle Lin   +7 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Probenecid relieves LPS-induced neuroinflammation by modulating the NLRP1 inflammasome pathway in BV2 cells

Scientific Reports
Inflammation is a key factor in neurodegenerative diseases (NDs) development, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Microglial cells maintain immune microenvironment homeostasis in the central nervous system (CNS) and are ...
Xiaoxuan Wang, Haozhe Tian, Shifei Chen, Liangliang Ying, Juan Zheng, Yaya Song, Jin Xi, Yuxin Zhang, Dong Wang   +8 more
doaj   +1 more source

Functionally heterogeneous porous scaffold design for tissue engineering [PDF]

, 2012
Most of the current tissue scaffolds are mainly designed with homogeneous porosity which does not represent the spatial heterogeneity found in actual tissues.
Khoda, AKM Bashirul, A. K. M. B. Khoda, Bahattin Koc, Koç, Bahattin, Khoda, AKM B.   +4 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source