Results 121 to 130 of about 3,009,910 (332)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

open access: yesMolecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh   +5 more
wiley   +1 more source

Research and development program for radiation measurements of radiobiological hazards of man in space Summary technical report, 1 Aug. 1965 - 31 Jul. 1966 [PDF]

open access: yes
Macroscopic and microscopic distribution of dose deposited in tissue by high energy protons - spherical proportional counters and silicon Au-i-Al ...

core   +1 more source

Distinct expression patterns of ER alpha and ER beta in normal human mammary gland [PDF]

open access: yes, 2002
AIM: Two oestrogen receptors (ERs) have been identified to date—the “classic” ERa and the more recently described ERb. Although much is known about ERa at the mRNA and protein levels, our knowledge of the expression and distribution of ERb protein is ...
Burdall, S.E.   +3 more
core  

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

open access: yesMolecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha   +10 more
wiley   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

open access: yesMolecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik   +4 more
wiley   +1 more source

Non‐Rayleigh Statistics of Ultrasonic Backscattered Echo from Tissues [PDF]

open access: yes, 1994
The envelope of the backscattered signal from tissues can exhibit non‐Rayleigh statistics if the number density of scatterers is small or if the variations in the scattering cross sections are random. The K distribution which has been used extensively in
Molthen, Robert C.   +3 more
core   +1 more source

Synergistic Nanocomposites of Different Antibiotics Coupled with Green Synthesized Chitosan-Based Silver Nanoparticles: Characterization, Antibacterial, in vivo Toxicological and Biodistribution Studies

open access: yesInternational Journal of Nanomedicine, 2020
Muhammad Arif Asghar,1 Rabia Ismail Yousuf,1 Muhammad Harris Shoaib,1 Muhammad Asif Asghar,2 Sabah Ansar,3 Mehrukh Zehravi,4 Ahad Abdul Rehman5 1Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi ...
Asghar MA   +6 more
doaj  

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