Results 81 to 90 of about 8,279,566 (317)

Persistent Contamination of Octopuses and Mussels with Lipophilic Shellfish Toxins during Spring Dinophysis Blooms in a Subtropical Estuary

Marine Drugs, 2015
This study investigates the occurrence of diarrhetic shellfish toxins (DSTs) and their producing phytoplankton species in southern Brazil, as well as the potential for toxin accumulation in co-occurring mussels (Perna perna) and octopuses (Octopus ...
Luiz L. Mafra, Daiana Lopes, Vanessa C. Bonilauri, Hajime Uchida, Toshiyuki Suzuki   +4 more
doaj   +1 more source

Estimated tissue-plasma distribution coefficients for MPH.

, 2014
Estimated tissue-plasma distribution coefficients for MPH.
Xiaoxia Yang (625366), Jeffery M. Gearhart (625368), Christopher D. Ruark (625369), Donald R. Mattison (625370), Merle G. Paule (286185), Nathan C. Twaddle (625372), Daniel R. Doerge (216203), John F. Young (625373), Jeffrey W. Fisher (625374), Benedetto Vitiello (625371), Suzanne M. Morris (625367), William Slikker Jr (583619)   +11 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Physiological Stress Signatures of Waterborne Glyphosate Exposure in Apostichopus japonicus: Insights for Aquatic Ecotoxicology

Toxics
Glyphosate is a widely used herbicide with increasing concern regarding its non-target impacts in coastal ecosystems and mariculture species. Here, we profiled acute physiological stress signatures of waterborne glyphosate exposure in the sea cucumber ...
Jingchun Sun, Shaoping Kuang, Hongsheng Yang   +2 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Metabolomic Study of 7-Ethyl-9-(N-methyl)aminomethyl-10-hydroxycamptothecin Derivative (NMe)—The Chemotherapeutic Drug Candidate Versus Irinotecan (IR) on a Mouse Model

Metabolites
Background: In this study, we aimed to compare metabolomic profiles, biodistribution, and detoxification patterns of the novel SN-38 derivative NMe with irinotecan (IR), and to identify NMe-specific metabolites to evaluate its preclinical pharmacokinetic
Piotr Surynt, Beata Naumczuk, Magdalena Popławska, Magdalena Urbanowicz, Katarzyna Unrug-Bielawska, Magdalena Cybulska-Lubak, Zuzanna Sadowska-Markiewicz, Jerzy Sitkowski, Elżbieta Bednarek, Natalia Zeber-Lubecka, Lech Kozerski, Michał Mikula, Jerzy Ostrowski   +12 more
doaj   +1 more source

Pharmacokinetics, Tissue Distribution, Plasma Protein Binding Studies of 10-Dehydroxyl-12-Demethoxy-Conophylline, a Novel Anti-Tumor Candidate, in Rats

Molecules, 2019
10-Dehydroxyl-12-demethoxy-conophylline is a natural anticancer candidate. The motivation of this study was to explore the pharmacokinetic profiles, tissue distribution, and plasma protein binding of 10-dehydroxyl-12-demethoxy-conophylline in Sprague ...
Chengjun Jiang, Jie Li, Xianghai Cai, Nini Li, Yan Guo, Dianlei Wang   +5 more
doaj   +1 more source

Pharmacokinetics and tissue distribution of gentiopicroside following oral and intravenous administration in mice

, 2004
The pharmacokinetics and tissue distribution of Gentiopicroside (GPS), one of the major active components of the Gentiana species of medicinal plants, was studied following oral and intravenous administration in mice.
Wang, C.-H., Branford-White, C.J., White, K.N., Wang, Z., Bligh, S.W.A.   +4 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Toxicity and Biokinetics of Colloidal Gold Nanoparticles

Nanomaterials, 2015
Gold nanoparticles (Au-NPs) have promising potential for diverse biological application, but it has not been completely determined whether Au-NP has potential toxicity in vitro and in vivo.
Mi-Rae Jo, Song-Hwa Bae, Mi-Ran Go, Hyun-Jin Kim, Yun-Gu Hwang, Soo-Jin Choi   +5 more
doaj   +1 more source