Results 81 to 90 of about 7,939,784 (316)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Physiological Functions and Molecular Mechanisms of Neurokinin B in Fish

Progress in Fishery Sciences
Neurokinin B (NKB) is a hypothalamic neuropeptide containing 10 amino acids and is an essential member of the tachykinin family. Based on studies in mammals, Kiss, NKB, and dynorphin A are located in the common neurons, named KNDy neurons, and NKB and ...
Bin WANG, Zhenfang TIAN, Huiying GUO, Yongjiang XU, Aijun CUI, Yan JIANG   +5 more
doaj   +1 more source

THE DISTRIBUTION OF METABOLITES IN THE BLOOD AND TISSUES [PDF]

Archives of Internal Medicine, 1922
INTRODUCTION With the introduction of simple and reliable microchemical methods of analysis, the determination of the concentration of metabolites in the blood has become an accepted clinical procedure. Consequently, the relation of metabolites in the blood to their distribution throughout the entire organism is a subject of clinical as well as ...
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Toxicokinetics and Tissue Distribution of the Hepatotoxic Triterpenoid Saponin Pterocephin A in Rats Using the Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry (UPLC-MS/MS) Method

Molecules
Pterocephin A is a natural triterpenoid saponin isolated from Pterocephalus hookeri, a traditional Tibetan medicine with slight toxicity, which can induce liver injury in rats.
Yiran Xiong, Zhaoyue Dong, Hongxu Zhou, Jingxin Mao, Lingjiang Zeng, Yunbin Jiang, Fancheng Meng, Zhihua Liao, Min Chen   +8 more
doaj   +1 more source

PEPTIDASE DISTRIBUTION IN LYMPHATIC TISSUE [PDF]

The Journal of Cell Biology, 1955
The lymphatic tissue of the rabbit contains a labile peptidase as measured by the hydrolysis of alanylglycine. Some characteristics of the enzyme were determined. This enzyme increases in amount when the numbers of macrophages in the tissue are increased and it is also present in the extracellular fluid in high concentration.
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Selective Tissue Distribution Mediates Tissue-Dependent PPARγ Activation and Insulin Sensitization by INT131, a Selective PPARγ Modulator

Frontiers in Pharmacology, 2017
The mechanisms underlying the enhancement of insulin sensitivity by selective peroxisome proliferator-activated receptor γ modulators (sPPARγMs) are still not completely known.
Xinni Xie, Xinni Xie, Xinni Xie, Wei Chen, Wei Chen, Ning Zhang, Ning Zhang, Mei Yuan, Mei Yuan, Cheng Xu, Zhibing Zheng, Zhibing Zheng, Hua Li, Hua Li, Lili Wang, Lili Wang   +15 more
doaj   +1 more source

Tissue Distribution of 212Bi in Rats

Experimental Biology and Medicine, 1969
SummaryThe 212Bi, relatively free of its parent 212Pb was injected intravenously into rats and the tissue distribution and was followed for a period of 2 hr postinjection. The kidney contained the highest concentration, equal to about 10 times that of the liver and spleen.
J B, Hursh, C, Brown
openaire   +2 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source