Results 61 to 70 of about 7,939,784 (316)

Effects of ultra-purified polymerized bovine hemoglobin on local tissue oxygen tension in striated skin muscle - An efficacy study in the hamster [PDF]

, 2002
The development of hemoglobin-based oxygen carriers has been propagated for replacement of the oxygen carrying properties of red blood cells for almost one century.
Nolte, Dirk, Botzlar, Andreas, Steinhauser, Peter   +2 more
core   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Infective SARS-CoV-2 in Skull Sawdust at Autopsy, Finland

Emerging Infectious Diseases
We assessed the distribution of SARS-CoV-2 at autopsy in 22 deceased persons with confirmed COVID-19. SARS-CoV-2 was found by PCR (2/22, 9.1%) and by culture (1/22, 4.5%) in skull sawdust, suggesting that live virus is present in tissues postmortem ...
Jonas N. Kantonen, Suvi Kuivanen, Teemu Smura, Henri Puttonen, Eliisa Kekäläinen, Antti Sajantila, Liisa Myllykangas, Anu Kantele, Olli Vapalahti, Mikko I. Mäyränpää, Olli Carpén   +10 more
doaj   +1 more source

New Insights Into the Evolution of Corticotropin-Releasing Hormone Family With a Special Focus on Teleosts

Frontiers in Endocrinology, 2022
Corticotropin-releasing hormone (CRH) was discovered for its role as a brain neurohormone controlling the corticotropic axis in vertebrates. An additional crh gene, crh2, paralog of crh (crh1), and likely resulting from the second round (2R) of ...
Gersende Maugars, Gersende Maugars, Xavier Mauvois, Patrick Martin, Salima Aroua, Karine Rousseau, Sylvie Dufour   +6 more
doaj   +1 more source

A Situational Assessment of the Diagnostic Landscape and Organizational Readiness to Implement Next‐Generation Sequencing at Two Childhood Cancer Treatment Centers in Ghana

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Next‐generation sequencing (NGS) has emerged as a promising approach to improve diagnostic accuracy, but its feasibility in low‐ and middle‐income countries remains unknown. This study characterized the diagnostic landscape and assessed organizational readiness for NGS implementation at two childhood cancer treatment centers in Accra ...
Melissa Carvalho, Emmanuella Amoako, Nihad Salifu, Lily Gloria Tagoe, Yaw Bediako, Michelle Hermiston, Catherine Segbefia   +6 more
wiley   +1 more source

Pharmacokinetics, tissue distribution, and metabolites of a polyvinylpyrrolidone-coated norcantharidin chitosan nanoparticle formulation in rats and mice, using LC-MS/MS

International Journal of Nanomedicine, 2012
Xin-Yuan Ding1, Cheng-Jiao Hong2, Yang Liu1, Zong-Lin Gu1, Kong-Lang Xing1, Ai-Jun Zhu1, Wei-Liang Chen1, Lin-Seng Shi1, Xue-Nong Zhang1, Qiang Zhang31Department of Pharmaceutics, College of Pharmaceutical science, Soochow University, Suzhou, 2Jiang Su ...
Ding XY, Hong CJ, Liu Y, Gu ZL, Xing KL, Zhu AJ, Chen WL, Shi LS, Zhang XN, Zhang Q   +9 more
doaj  

Occurrence, Profile, and Potential Risks of Novel and Legacy Polyfluoroalkyl Substances in Bullfrogs: Pilot Study in an Intensive Aquaculture Region, China

Frontiers in Environmental Science, 2021
Per- and polyfluoroalkyl substances (PFASs) have captured worldwide attention due to their persistent and bioaccumulative characteristics. The bullfrog is a highly nutritious and edible aquatic product, but the PFAS accumulation characteristics of ...
Qiongping Sun, Yonglong Xiong, Ran Bi, Ran Bi, Xinyi Zhan, Yueyao Fan, Chuanghong Su, Zhenwei Chen, Zhao Zheng, Zhao Zheng, Jieyi Diao, Tieyu Wang   +11 more
doaj   +1 more source

Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes [PDF]

, 2011
The discovery of substantial amounts of 5-hydroxymethylcytosine (5hmC), formed by the oxidation of 5-methylcytosine (5mC), in various mouse tissues and human embryonic stem (ES) cells has necessitated a reevaluation of our knowledge of 5mC/5hmC patterns ...
Sproul, Duncan, Richard R. Meehan, Katz, Elad,, Nestor, Colm E., Meehan, Richard R,, Elad Katz, Dixon, J Michael,, Harrison, David James, Dixon, J. Michael, Raffaele Ottaviano, Dunican, Donncha, Sproul, Duncan,, Colm E. Nestor, Meehan, Richard R, Dunican, Donncha,, Nestor, Colm,, Reddington, James,, Duncan Sproul, David J. Harrison, Nestor, Colm E, Dunican, Donncha; id_orcid, Harrison, David J, James Reddington, Donncha Dunican, Reddington, James, Reinhardt, Diana,, J. Michael Dixon, Ottaviano, Raffaele,, Katz, Elad, Ottaviano, Raffaele, Dixon, J Michael, Meehan, Richard R., Reinhardt, Diana, Diana Reinhardt, Harrison, David J,   +34 more
core   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source