Results 131 to 140 of about 439,003 (336)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Retrospective study of COVID-19 seroprevalence among tissue donors at the onset of the outbreak before implementation of strict lockdown measures in France. [PDF]

Cell Tissue Bank, 2021
Germain N, Herwegh S, Hatzfeld AS, Bocket L, Prévost B, Danzé PM, Marchetti P.   +6 more
europepmc   +1 more source

Identification and tissue distribution of antigen-specific recipient anti-donor CD8+ T cells that resist hematopietic engraftment following MHC-matched allogeneic progenitor cell transplants [PDF]

, 2005
Alwi M. Shatry, Robert B. Levy
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Knowledge and Attitude Regarding Organ Donation among Relatives of Patients Referred to the Emergency Department

Emergency, 2015
Introduction: Organ donation is one of the surviving procedures which can increase the life expectancy of end-stage patients. Inappropriate beliefs and attitude of individuals to organ donation, their poor knowledge, and the socio-economic level are one ...
Mahboob Pouraghaei, Mohammad Tagizadieh, Ali Tagizadieh, Payman Moharamzadeh, Samaneh Esfahanian, kavous Shahsavari Nia   +5 more
doaj  

Implementation Intentions as a Strategy to Increase the Notification Rate of Potential Ocular Tissue Donors by Nurses: A Clustered Randomized Trial in Hospital Settings

Nursing Research and Practice, 2014
Aim. The purpose of this study is to evaluate the impact, among nurses in hospital settings, of a questionnaire-based implementation intentions intervention on notification of potential ocular tissue donors to donation stakeholders. Methods.
Frédéric Douville, Gaston Godin, France Légaré, Marc Germain   +3 more
doaj   +1 more source

A Comparative Analysis between Totipotency and Growth Environment Conditions of the Donor Plants in Tissue Culture of Zea mays L. [PDF]

, 1986
Mário A. Santos, J. M. Torné
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Validating potential organ and tissue donors in the middle of the COVID-19 pandemic: Scoping review and recommendations construction. [PDF]

Enferm Intensiva (Engl Ed), 2022
da Silva-Knihs N, Erbs-Pessoa JL, Pestana-Magalhães AL, Schuantes-Paim SM, Fischer-Wachholz L, Lima-Silva E, de Aguiar-Roza B.   +6 more
europepmc   +1 more source

PD-1-Dependent Mechanisms Maintain Peripheral Tolerance of Donor-Reactive CD8+ T Cells to Transplanted Tissue [PDF]

, 2008
Brent H. Koehn, Mandy L. Ford, Ivana R. Ferrer, Keshawna Borom, Shivaprakash Gangappa, Allan D. Kirk, Christian P. Larsen   +6 more
openalex   +1 more source