Results 251 to 260 of about 439,003 (336)

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Mumps virus infection triggers early pro-inflammatory responses and impairs Leydig and Sertoli cell function in an ex vivo human testis model. [PDF]

Hum Reprod
Franklin L, Kuassivi ON, Satie AP, Abiven H, Mathieu R, Miaadi N, Plotton I, Le Tortorec A, Dejucq-Rainsford N.   +8 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Fibroblast diversity within human gut-associated lymphoid tissues. [PDF]

J Exp Med
Mörbe UM, Junghus FV, Nos G, Jørgensen PB, Ensmenger MJ, Väänänen VA, Wewer MD, Madsen GR, Riis LB, Jakobsen HL, Olsen LR, Brunak S, Nielsen OH, Agace WW.   +13 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils. [PDF]

Immunity
Sureshchandra S, Henderson J, Levendosky E, Bhattacharyya S, Kastenschmidt JM, Sorn AM, Mitul MT, Yates TB, Cheng E, Benchorin A, Batucal K, Daugherty A, Murphy SJH, Thakur C, Trask D, Ahuja G, Zhong Q, Moisan A, Tiffeau-Mayer A, Saligrama N, Wagar LE.   +20 more
europepmc   +1 more source

Investigating the Use of Companion Animal Donor Tissue Banks

Kaitlin Mitchell, L.F. Carver
openalex   +2 more sources

The role of donor versus recipient tissue factor in coagulopathy during pig-to-primate xenotransplantation

, 2010
Chih Che Lin
openalex   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Effect of Aging on the Morphofunctional Characteristics of Oral Cavity Mesenchymal Stromal Cells: A Scoping Review. [PDF]

Biomedicines
Alarcón-Apablaza J, Salazar LA, Loren P, Martínez-Cardozo C, Fuentes R.   +4 more
europepmc   +1 more source