Results 61 to 70 of about 3,873,709 (285)

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source

Dynamic mode decomposition based Doppler monitoring of de novo cavitation induced by pulsed HIFU: an in vivo feasibility study

Scientific Reports
Pulsed high-intensity focused ultrasound (pHIFU) has the capability to induce de novo cavitation bubbles, offering potential applications for enhancing drug delivery and modulating tissue microenvironments.
Minho Song, Oleg A. Sapozhnikov, Vera A. Khokhlova, Helena Son, Stephanie Totten, Yak-Nam Wang, Tatiana D. Khokhlova   +6 more
doaj   +1 more source

Right Ventricular Tissue Doppler in Space Flight [PDF]

, 2010
The presentation slides review normal physiology of the right ventricle in space, general physiology of the right ventricle; difficulties in imaging the heart in space, imaging methods, tissue Doppler spectrum, right ventricle tissue Doppler, and Rt Tei ...
Sargsyan, Ashot E., Hamilton, Douglas R., Barratt, Michael R., Ebert, Douglas, Martin, David S., Bogomolov, Valery V., Dulchavsky, Scott A., Duncan, J. Michael, Garcia, Kathleen M.   +8 more
core  

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Intracardiac Shunts and Role of Tissue Doppler Imaging in Diagnosis and Discrimination [PDF]

Journal of Tehran University Heart Center, 2008
Background: We sought to assess right ventricular (RV) systolic and diastolic functions via tissue Doppler imaging (TDI) in order to discriminate right-to-left (bidirectional) from left-to-right intracardiac shunts.
Mohammad Asadpour Piranfar, Mersedeh Karvandi, Arash Mohammadi Tofigh   +2 more
doaj   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Doppler tissue imaging to assess systolic function in Chagas' disease

Arquivos Brasileiros de Cardiologia, 2003
OBJECTIVE: To assess the usefulness of Doppler tissue imaging (DTI) for evaluating the systolic function of chagasic patients with and without electrocardiographic abnormalities, in comparision with echocardiographic study.
Barros Márcio Vinícius Lins, Ribeiro Antonio Luiz Pinho, Machado Fernando Santana, Rocha Manoel Otávio da Costa   +3 more
doaj   +3 more sources

Echo-driven V-V optimization determines clinical improvement in non responders to cardiac resynchronization treatment

Cardiovascular Ultrasound, 2006
Echocardiography plays an integral role in the detection of mechanical dyssynchrony in patients with congestive heart failure and in predicting beneficial response to cardiac resynchronization treatment.
Peter C Thomas, Rafique Asim M, Naqvi Tasneem Z   +2 more
doaj   +1 more source

Single camera three component planar velocity measurements using two-frequency planar Doppler velocimetry (2ν-PDV) (2012) [PDF]

, 2006
Two-frequency planar Doppler velocimetry (2ν-PDV) is used in conjunction with imaging fibre bundles to make time-averaged three component velocity measurements using a single CCD camera and iodine cell. In this scheme the flow is sequentially illuminated
Charrett, Thomas O. H., Tatam, Ralph P.
core   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source