Results 121 to 130 of about 4,427,559 (374)

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

open access: yesFEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik   +3 more
wiley   +1 more source

Elevated Pressure Improves the Rate of Formalin Penetration while Preserving Tissue Morphology

open access: yesJournal of Cancer, 2010
Formaldehyde fixation and paraffin-embedding remains the most widely used technique for processing cancer tissue specimens for pathologic examination, the study of tissue morphology, and archival preservation.
Ingrid E. Chesnick, Jeffrey T. Mason, Timothy J. O'Leary, Carol B. Fowler
doaj  

Pilon Fractures: Update on treatment

open access: yesJournal of the Foot & Ankle
Tibial pilon fractures (plafond) are severe injuries resulting from predominately axial impaction. They are typically accompanied by severe damage to the vulnerable soft tissue envelope and the articular damage, making these fractures prone to ...
Franco Mombello   +2 more
doaj   +1 more source

In Vivo Kinematic Analysis of Lateral Meniscal Allograft Transplantation With Soft Tissue Fixation. [PDF]

open access: yesOrthop J Sports Med, 2021
Macchiarola L   +6 more
europepmc   +1 more source

Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS‐PAGE with low acrylamide concentration

open access: yesFEBS Open Bio, EarlyView.
SLC7A11 frequently migrates faster in SDS‐PAGE. The present study found that the high hydrophobicity of SLC7A11 causes its anomalous migration in SDS‐PAGE with a low concentration of acrylamide gel. Replacing isoleucine with asparagine reduced hydrophobicity and restored its normal migration at 55 kDa, revealing the role of hydrophobicity and gel ...
Nsengiyumva Emmanuel   +13 more
wiley   +1 more source

A Technique of Superficial Medial Collateral Ligament Reconstruction Using an Adjustable-Loop Suspensory Fixation Device

open access: yesArthroscopy Techniques, 2015
This report describes superficial medial collateral ligament reconstruction of the knee using a novel method of graft fixation with the ACL Tightrope RT (Arthrex, Naples, FL).
Shaneel Deo, B.H.B.(Hons), M.B.Ch.B., F.R.A.C.S.   +1 more
doaj  

Computational simulation of bone remodelling post reverse total shoulder arthroplasty [PDF]

open access: yesarXiv, 2017
Bone is a living material. It adapts, in an optimal sense, to loading by changing its density and trabeculae architecture - a process termed remodelling. Implanted orthopaedic devices can significantly alter the loading on the surrounding bone, which can have a detrimental impact on bone ingrowth that is critical to ensure secure implant fixation.
arxiv  

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

open access: yesFEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang   +9 more
wiley   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

open access: yesFEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren   +8 more
wiley   +1 more source

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