Results 51 to 60 of about 2,390,613 (305)

Formalin fixation affects equilibrium partitioning of an ionic contrast agent-microcomputed tomography (EPIC-μCT) imaging of osteochondral samples [PDF]

, 2010
Osteoarthritis Cartilage. 2010 Dec;18(12):1586-91. Epub 2010 Oct 13. Formalin fixation affects equilibrium partitioning of an ionic contrast agent-microcomputed tomography (EPIC-μCT) imaging of osteochondral samples.
Benders, K.E.M., Tissue Repair, J. Malda, D.B.F. Saris, K.E.M. Benders, Hutmacher, D., Hutmacher, D.W., Klein, T., Steck, R., R. Steck, Saris, D.B.F., Saris, Daniël B.F., T.J. Klein, Saris, D., Dhert, W., Geneeskunde van gezelschapsdieren, Malda, J., D.W. Hutmacher, Benders, K., Klein, T.J., W.J.A. Dhert, Dhert, W.J.A.   +21 more
core   +2 more sources

Fixation-induced shrinkage of spine heads but not PSD area.

, 2021
(A) TEM images of L2/3 SSC acute slices from the same mouse (postnatal day P21) upon either chemical fixation with aldehydes (A1) or physical fixation with HPF (A2). Spine head section areas (indicated in red in A1 and in light blue in A2) and lengths of
Matteo Fossati (11326806), Philippe Rostaing (171355), Antoine Triller (142658), Nora Assendorp (11326803), Pablo Serna (8703291), Cécile Charrier (11326809), Olivier Gemin (11326797), Joseph Zamith (11326800)   +7 more
core   +1 more source

Shrinkage of Nasal Mucosa and Cartilage during Formalin Fixation

Balkan Medical Journal, 2017
Background:After resection, specimens are subjected to formalin fixation during histologic processing. This procedure can result in tissue shrinkage, with amount of shrinkage related to tissue composition and tissue type. Aims: In this study,we aimed to
Leyla Kansu, Erdinç Aydın, Hampar Akkaya, Suat Avcı, Nalan Akalın   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Adipose derived tissue engineered heart valve [PDF]

, 2015
Introduction: A major challenge associated with heart valve tissue engineering is the in vitro creation of mature tissue structures compliant with native valve functionality.
Baaijens, FPT Frank, Beer, G M, Driessen - Mol, A., Hoerstrup, S., Beer, G.M., Baaijens, Frank P T, Baaijens, F.P.T., Weber, B., Hoerstrup, S P, Driessen-Mol, Anita, Frese, Laura, Frese, L., Driessen-Mol, A Anita, Weber, Benedikt, Beer, Gertrude M, Sanders, B Bart, Hoerstrup, S Simon, Sanders, Bart, Sanders, B.   +18 more
core   +2 more sources

Evaluation of the effects of clearing agents, fixation, and process durations on cardiovascular tissue imaging with second harmonic generation and multi-photon modalities

Frontiers in Bioengineering and Biotechnology
IntroductionProtocols for tissue clearing have been established and optimized for the central nervous system. However, significant modifications are required for clearing different tissue types.
Maedeh Makki, Zachary A. Molander, Sergio A. Pineda-Castillo, Devin W. Laurence, Shubhra Singhal, Yasmin Eltwafsha, Gerhard A. Holzapfel, Gerhard A. Holzapfel, Tingting Gu, Chung-Hao Lee   +9 more
doaj   +1 more source

Medial external fixation for staged treatment of closed calcaneus fractures: Surgical technique and case series

Journal of Orthopaedic Surgery, 2017
The derangement in calcaneal morphology after a fracture can be significant and is often associated with severe soft tissue envelop problems. Medial calcaneal external fixation is useful for early restoration of calcaneal morphology and the corresponding
Michael Githens, Joshua Shatsky, Julie Agel, Richard J Bransford, Stephen K Benirschke   +4 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source