Results 71 to 80 of about 389,621 (264)

Histological evaluation of PAXgene tissue fixation in Barrett's esophagus and esophageal adenocarcinoma diagnostics. [PDF]

Virchows Arch, 2023
Barroux M, Horstmann J, Fricke L, Schömig L, Werner M, Kraynova E, Kamarádová K, Fléjou JF, Maerkel B, Kumarasinghe MP, Vieth M, Westerhoff M, Patil DT, Steiger K, Becker KF, Weichert W, Schmid RM, Quante M, Slotta-Huspenina J.   +18 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Histological assessment of PAXgene tissue fixation and stabilization reagents.

PLoS ONE, 2011
Within SPIDIA, an EC FP7 project aimed to improve pre analytic procedures, the PAXgene Tissue System (PAXgene), was designed to improve tissue quality for parallel molecular and morphological analysis.
Marcel Kap, Frank Smedts, Wolter Oosterhuis, Rosa Winther, Nanna Christensen, Bilge Reischauer, Christian Viertler, Daniel Groelz, Karl-Friedrich Becker, Kurt Zatloukal, Rupert Langer, Julia Slotta-Huspenina, Koppany Bodo, Bas de Jong, Uwe Oelmuller, Peter Riegman   +15 more
doaj   +1 more source

Effect of tissue fixation on the optical properties of structural components assessed by non-linear microscopy imaging. [PDF]

Biomed Opt Express, 2023
Markus MA, Ferrari DP, Alves F, Ramos-Gomes F.   +3 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Assessing Tissue Fixation Time and Quality with Label-free Mid Infrared Spectroscopy and Machine Learning. [PDF]

Biopreserv Biobank, 2023
Bauer DR, Chafin DR.
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Endoscopic-Assisted Fibula Reduction With Full Percutaneous Fixation of Ankle Fracture Dislocation

Arthroscopy Techniques
Ankle fracture is one of the most commonly encountered fractures. Open reduction and internal fixation is the gold standard of treatment. However, minimally invasive fixation of ankle fracture is gaining popularity among foot and ankle surgeons as the ...
Chau Ming Hong, M.B.Ch.B., F.H.K.C.O.S., F.H.K.A.M. (Orthopaedic Surgery), F.R.C.S.Ed. (Orth.), M.R.C.S.Ed., Liu Stephanie Ka Ki, M.B.B.S., F.H.K.C.O.S., F.H.K.A.M. (Orthopaedic Surgery), F.R.C.S.Ed. (Orth.), F.H.K.C.O.S. (Rehabilitation), M.R.C.S.Ed.   +1 more
doaj   +1 more source

A Simple Technique for Reconstruction of the Medial Patellofemoral Ligament With Patellar Soft-Tissue Fixation Using Synthetic Suture Tape Internal Bracing. [PDF]

Arthrosc Tech, 2023
Berger P, Vandenneucker H, Bellemans J.
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source