Results 71 to 80 of about 393,517 (265)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Histological assessment of PAXgene tissue fixation and stabilization reagents.

PLoS ONE, 2011
Within SPIDIA, an EC FP7 project aimed to improve pre analytic procedures, the PAXgene Tissue System (PAXgene), was designed to improve tissue quality for parallel molecular and morphological analysis.
Marcel Kap, Frank Smedts, Wolter Oosterhuis, Rosa Winther, Nanna Christensen, Bilge Reischauer, Christian Viertler, Daniel Groelz, Karl-Friedrich Becker, Kurt Zatloukal, Rupert Langer, Julia Slotta-Huspenina, Koppany Bodo, Bas de Jong, Uwe Oelmuller, Peter Riegman   +15 more
doaj   +1 more source

Using a reconstruction locking compression plate as external fixator in infected open clavicle fracture

Orthopedic Reviews, 2013
Open clavicle fracture is an uncommon injury mostly caused by severe direct trauma. It is often associated with multiple organ injuries. Generally, surgical intervention with debridement and fracture repair is always indicated in order to prevent ...
Norachart Sirisreetreerux, Paphon Sa-ngasoongsong, Pongsthorn Chanplakorn, Noratep Kulachote, Sukij Laohajaroensombat, Chanyut Suphachatwong, Vajara Phiphobmongkol, Wiwat Wajanavisit   +7 more
doaj   +1 more source

Assessing Tissue Fixation Time and Quality with Label-free Mid Infrared Spectroscopy and Machine Learning. [PDF]

Biopreserv Biobank, 2023
Bauer DR, Chafin DR.
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Endoscopic-Assisted Fibula Reduction With Full Percutaneous Fixation of Ankle Fracture Dislocation

Arthroscopy Techniques
Ankle fracture is one of the most commonly encountered fractures. Open reduction and internal fixation is the gold standard of treatment. However, minimally invasive fixation of ankle fracture is gaining popularity among foot and ankle surgeons as the ...
Chau Ming Hong, M.B.Ch.B., F.H.K.C.O.S., F.H.K.A.M. (Orthopaedic Surgery), F.R.C.S.Ed. (Orth.), M.R.C.S.Ed., Liu Stephanie Ka Ki, M.B.B.S., F.H.K.C.O.S., F.H.K.A.M. (Orthopaedic Surgery), F.R.C.S.Ed. (Orth.), F.H.K.C.O.S. (Rehabilitation), M.R.C.S.Ed.   +1 more
doaj   +1 more source

A Simple Technique for Reconstruction of the Medial Patellofemoral Ligament With Patellar Soft-Tissue Fixation Using Synthetic Suture Tape Internal Bracing. [PDF]

Arthrosc Tech, 2023
Berger P, Vandenneucker H, Bellemans J.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Revisiting PFA-mediated tissue fixation chemistry: <i>FixEL</i> enables trapping of small molecules in the brain to visualize their distribution changes. [PDF]

Chem, 2023
Nonaka H, Mino T, Sakamoto S, Oh JH, Watanabe Y, Ishikawa M, Tsushima A, Amaike K, Kiyonaka S, Tamura T, Aricescu AR, Kakegawa W, Miura E, Yuzaki M, Hamachi I.   +14 more
europepmc   +1 more source