Results 131 to 140 of about 140,500 (312)

Tetracycline Actions Relevant to Rosacea Treatment [PDF]

, 2009
Until today, the pathogenesis of rosacea is not known in detail. Yet in recent years evidence has been accumulating that rosacea with its common symptoms such as inflammatory lesions, erythema, telangiectasia, phymatous changes, and ocular symptoms is of
Korting, Hans Christian, Schöllmann, C.
core   +1 more source

Effects of benazepril on renal function and kidney expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in diabetic rats

Chinese Medical Journal, 2006
Excessive deposition of extracellular matrix (ECM) in the kidney is the hallmark of diabetic nephropathy. Increased matrix synthesis has been well documented but the effects of diabetes on degradative pathways, particularly in the in vivo setting. The renal protective effect of these pathways on matrix accumulation has not been fully elucidated.
Shu-zhen, Sun, Yi, Wang, Qian, Li, Yong-jie, Tian, Ming-hua, Liu, Yong-hui, Yu   +5 more
openaire   +2 more sources

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

JNK suppression is essential for 17β-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells

Journal of Biomedical Science, 2011
Background Epidemiological studies demonstrate that the incidence and mortality rates of colorectal cancer in women are lower than in men. However, it is unknown if 17β-estradiol treatment is sufficient to inhibit prostaglandin E2 (PGE2)-induced cellular
Chen Wei-Kung, Chen Li-Mien, Kuo Wei-Wen, Lin Yueh-Min, Hu Wei-Syun, Hsu Hsi-Hsien, Hwang Jin-Ming, Tsai Fuu-Jen, Liu Chung-Jung, Huang Chih-Yang   +9 more
doaj   +1 more source

ADAM15 modulates outside-in signalling in chondrocyte–matrix interactions [PDF]

, 2008
ADAM15 belongs to a family of transmembrane multi-domain proteins implicated in proteolysis, cell–cell and cell–matrix interactions in various disease conditions.
Burkhardt, Harald, Böhm, Beate B., Schirner, Andrea   +2 more
core   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases 2 in the diagnosis of colorectal adenoma and cancer patients

Folia Histochemica et Cytobiologica, 2010
The aim of the study was to assess the importance of the measurement of matrix metalloproteinase 2 (MMP-2)and tissue inhibitor of matrix metalloproteinases 2 (TIMP-2) in patients with colorectal cancer (CRC) in relation to clinicopathologicalfeatures of ...
Magdalena Groblewska, Barbara Mroczko, Mariusz Gryko, Boguslaw Kędra, Maciej Szmitkowski   +4 more
doaj  

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF [PDF]

, 2013
Several pathological processes, such as sepsis and inflammatory bowel disease (IBD), are associated with impairment of intestinal epithelial barrier. Here, we investigated the role of matrix metalloproteinase MMP13 in these diseases.
Albanese CT, An Staes, Carlos López‐Otin, Claude Libert, Elien Van Wonterghem, Eline Dejonckheere, Filip Van Hauwermeiren, Kitagawa H, Kris Gevaert, Lesuffleur T, Nusrat A, Riet De Rycke, Roosmarijn E. Vandenbroucke, Schmitz H, Smirnova MG, Sofie Lodens   +15 more
core   +3 more sources

Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 expression in fibrotic rat liver

World Journal of Gastroenterology, 2000
Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 expression in fibrotic rat ...
Hai-Lin, Liu, Xuan-Hai, Li, Dan-Yi, Wang, Shao-Ping, Yang   +3 more
openaire   +2 more sources