Results 151 to 160 of about 140,500 (312)

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Study of Matrix Metalloproteinases and Their Inhibitors in Blood Serum of Healthy Men of Different Ages Exposed to Risk Factors

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье
Aging is an irreversible process that proceeds individually in each case. It is known that the matrix metalloproteinase (MMP) system is involved in processes associated with aging.
E. V. Markelova, V. N. Yushchuk, N. S. Chepurnova, M. A. Visyagina, S. V. Knysh, E. A. Chagina   +5 more
doaj   +1 more source

Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction

Advanced Science, EarlyView.
We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang, Kai Dai, Tong Shen, Zehua Gao, Fengying Yan, Yuke Feng, Xuanlin Wang, Shaozhen Zhang, Jing Wang, Changsheng Liu   +9 more
wiley   +1 more source

SARS-CoV Regulates Immune Function-Related Gene Expressions in Human Monocytic Cells [PDF]

, 2011
Background: Severe Acute Respiratory Syndrome (SARS) is characterized by acute respiratory distress (ARDS) and pulmonary fibrosis, and the monocyte/macrophage is the key player in the pathogenesis of SARS. Methods: In this study, we ...
Betty A. Wu-Hsieh, Chuan-Liang Kao, Sher Singh, Wan-Jiung(Wan-Chung) Hu, Yu-Ting Yen   +4 more
core   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Serpin peptidase inhibitor, clade E, member 2 in physiology and pathology: recent advancements

Frontiers in Molecular Biosciences
Serine protease inhibitors (serpins) are the most numerous and widespread multifunctional protease inhibitor superfamily and are expressed by all eukaryotes.
Shutong Wu, Shutong Wu, Yuchao Yang, Yuchao Yang, Meiling Zhang, Asmat Ullah Khan, Jingxing Dai, Jun Ouyang   +7 more
doaj   +1 more source

Expression of MMP-13 in Human Temporomandibular Joint Disc Derangement and Osteoarthritis [PDF]

, 2017
Objective: MMP-13 performs digestion of collagen, which is a primary component of the temporomandibular joint (TMJ) articular disc. This study evaluated the expression of MMP-13 in patients with anterior disc displacement with (ADDwR) and without ...
Almeida, Luis Eduardo, Azevedo, Marina, Camejo, Flavio, Doetzer, Andrea, Olandoski, Marcia, Perotto, Juliano Henrique   +5 more
core   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Altered Bone Mechanics, Architecture and Composition in the Skeleton of TIMP-3-Deficient Mice [PDF]

, 2017
A Bruni-Cardoso, A Carriero, A Carriero, A Carriero, A Janssen, A Ural, Adele Boskey, AL Boskey, AL Boskey, Alessandra Carriero, Andrew A. Pitsillides, B Javaheri, Behzad Javaheri, BH Weber, Brendyn Miller, CH Turner, D Stickens, E Donnelly, E Ohuchi, EL Martin, EP Paschalis, FF Mohammed, George Bou-Gharios, H Isaksson, H Zhao, HH Malluche, J Verstappen, K Bell, K Brew, K Holmbeck, K Verdelis, KJ Leco, L Hammoud, L Spevak, Lyudmila Lukashova, Lyudmila Spevak, M Federici, M Inada, M Marzia, ME Marisa, ML Bouxsein, P Garnero, PW Fedak, R Ritchie, R Shigdel, S Sahebjam, S Verrier, SE Gill, SS Apte, T Maretzky, W Cruz-Munoz, Y Shen   +51 more
core   +3 more sources

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source