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The JNJ0966 Significantly Reduces the Elevated Serum MMP-9 and Blood Pressure Observed in SHRs With Periodontitis. [PDF]

Int Dent J
Guo G, Sheikh MM, Zhou M, Liao Y, Zhu E, Li B, He C, Li J, Zhou Q, Zhou W.   +9 more
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Matrix metalloproteinase‐2 regulates the expression of tissue inhibitor of matrix metalloproteinase‐2

Clinical and Experimental Pharmacology and Physiology, 2010
Summary1. Matrix metalloproteinases (MMP) are associated with the vascular remodelling seen in atherosclerosis and aneurysm. The activation and activity of MMP‐2 are regulated by the intrinsic tissue inhibitor of MMP‐2 (TIMP‐2). The aim of the present study was to examine whether, conversely, MMP‐2 can affect the gene and protein expression of TIMP‐2.2.
Kaoru, Kimura, Xian Wu, Cheng, Kae, Nakamura, Aiko, Inoue, Lina, Hu, Haizhen, Song, Kenji, Okumura, Akihisa, Iguchi, Toyoaki, Murohara, Masafumi, Kuzuya   +9 more
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Polymorphisms in the matrix metalloproteinase‐2 and tissue inhibitor of metalloproteinase‐2 and the risk of human adenomyosis

Environmental and Molecular Mutagenesis, 2008
AbstractThe matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) may contribute to the development of adenomyosis. The aim of the present study was to investigate whether three single nucleotide polymorphisms (SNPs) in the promoter regions of MMP‐2 (−1306C/T and −735C/T) and TIMP‐2 (‐418G/C) genes were related to the risk
Shan, Kang, Xiwa, Zhao, Huimin, Xing, Na, Wang, Rongmiao, Zhou, Shucheng, Chen, Wansheng, Li, Jian, Zhao, Yanan, Duan, Donglan, Sun, Yan, Li   +10 more
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Endometrial tumor invasiveness is related to metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 expressions

International Journal of Gynecological Cancer, 2006
Matrix metalloproteinase (MMPs) expression has been linked to gynecological tumor aggressiveness. The objective of this study was to determine MMP-2, MMP-7, and MMP-9 and tissue inhibitors of metalloproteinases (TIMP)-1 and TIMP-2 expression in endometrial malignancies and their relation to clinical and histologic parameters.
Graesslin, Olivier, Cortez, Annie, Uzan, C., Birembaut, Philippe, Quereux, Christian, Daraï, Emile   +5 more
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Erythropoietin Modulates Imbalance of Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 in Doxorubicin-induced Cardiotoxicity

Heart, Lung and Circulation, 2014
Doxorubicin (DOX) is a highly effective anti-cancer drug with limited clinical use due to its serious cardiotoxicity. Recent studies reported that erythropoietin (EPO) could exert a cardioprotective effect by non-erythropoietic effects. This study was to investigate fibrosis of DOX-induced cardiotoxicity and determine mechanisms of EPO against ...
Xing, Chen, Zhihua, Guo, Peixian, Wang, Miqing, Xu   +3 more
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Tissue Inhibitor of Metalloproteinase 2 and Coronary Artery Lesions in Kawasaki Disease

The Journal of Pediatrics, 2007
To identify cytokine genes uniquely expressed in peripheral blood mononuclear cells (PBMNCs) in the acute phase of Kawasaki disease (KD) with coronary artery lesions (CALs).We screened the mRNA expression levels of PBMNCs from 4 pairs of KD patients with and without CAL using DNA microarray.
Kenji, Furuno, Hidetoshi, Takada, Ken, Yamamoto, Kazuyuki, Ikeda, Takuro, Ohno, Vahid, Khajoee, Yumi, Mizuno, Toshiro, Hara   +7 more
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The Distribution of tissue inhibitor of metalloproteinases-2 (TIMP-2) in the human placenta

Placenta, 1996
Matrix metalloproteinases (MMPs) secreted by human cytotrophoblasts are crucial for the invasion of the placental bed by these cells. The invasive growth of the trophoblast is similar to that of malignant tumours in many respects, but, unlike the latter, it is strictly controlled.
P, Ruck, K, Marzusch, H P, Horny, J, Dietl, E, Kaiserling   +4 more
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Matrix metalloproteinases and tissue inhibitor of metalloproteinase-2 in fetal rabbit lung

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2000
Cell-extracellular matrix interaction and extracellular matrix remodeling are known to be important in fetal lung development. We investigated the localization of matrix metalloproteinases (MMPs) in fetal rabbit lungs. Immunohistochemistry for type IV collagen, MMP-1, MMP-2, MMP-9, membrane type (MT) 1 MMP, and tissue inhibitor of metalloproteinase ...
Y, Fukuda, M, Ishizaki, Y, Okada, M, Seiki, N, Yamanaka   +4 more
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Cloning and Regulation of Rat Tissue Inhibitor of Metalloproteinases-2 in Osteoblastic Cells

Archives of Biochemistry and Biophysics, 1994
Rat tissue inhibitor of metalloproteinases-2 (TIMP-2) was cloned from a UMR 106-01 rat osteoblastic osteosarcoma cDNA library. The 969-bp full-length clone demonstrates 98 and 86% sequence identity to human TIMP-2 at the amino acid and nucleic acid levels, respectively.
T F, Cook, J S, Burke, K D, Bergman, C O, Quinn, J J, Jeffrey, N C, Partridge   +5 more
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Serum levels of tissue inhibitor of metalloproteinases 2 in patients with systemic sclerosis

Journal of the American Academy of Dermatology, 2000
The serum tissue inhibitor of metalloproteinases 1 (TIMP-1) level was reported to be a useful indicator of disease activity, especially of lung fibrosis in patients with systemic sclerosis. TIMP-2 is also an important inhibitor of matrix metalloproteinases (MMPs), such as interstitial collagenase, gelatinase, and stromelysin, which control the ...
N, Yazawa, K, Kikuchi, H, Ihn, M, Fujimoto, M, Kubo, T, Tamaki, K, Tamaki   +6 more
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