Results 271 to 280 of about 158,026 (312)

Characterization of Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Human Plasma

Connective Tissue Research, 1992
In this study, we have identified and characterized metalloproteinases and tissue inhibitors of metalloproteinases (TIMPs) in human plasma. Treatment of plasma with trypsin or aminophenylmercuric acetate resulted in activation of latent gelatinolytic activity.
D, Moutsiakis, P, Mancuso, H, Krutzsch, W, Stetler-Stevenson, S, Zucker   +4 more
openaire   +2 more sources

Inhibition of angiogenesis by tissue inhibitor of metalloproteinase

Journal of Cellular Physiology, 1994
AbstractMatrix proteases play a critical role in cell invasion and migration, including the process of angiogenesis. The ability of specific factors to induce angiogenic responses correlates with their stimulation of matrix protease synthesis and release.
M D, Johnson, H R, Kim, L, Chesler, G, Tsao-Wu, N, Bouck, P J, Polverini   +5 more
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Quantification of matrix metalloproteinases and tissue inhibitors of metalloproteinase in prostatic tissue: Analytical aspects

The Prostate, 1998
The balance between matrix metalloproteinases (MMP) and the tissue inhibitors of metalloproteinases (TIMP) has been seen as important during tumor invasion and progression. The determination of these components needs a special strategy of tissue preparation.
K, Jung, M, Lein, N, Ulbrich, B, Rudolph, W, Henke, D, Schnorr, S A, Loening   +6 more
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Tissue inhibitors of metalloproteinases in liver fibrosis

The International Journal of Biochemistry & Cell Biology, 1997
Liver fibrosis and its end stage sequelae cirrhosis represent a major worldwide health problem. By definition progressive fibrosis occurs when the rate of matrix synthesis exceeds matrix degradation. Considerable evidence suggests that the hepatic stellate cell is central to the fibrotic process.
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Structural Basis of the Matrix Metalloproteinases and Their Physiological Inhibitors, the Tissue Inhibitors of Metalloproteinases

Biological Chemistry, 2003
The matrix metalloproteinases (MMPs) constitute a family of multidomain zinc endopeptidases with a metzincin-like catalytic domain, which are involved in extracellular matrix degradation but also in a number of other important biological processes. Under healthy conditions, their proteolytic activity is precisely regulated by their main endogenous ...
Bode, W., Maskos, K.
openaire   +3 more sources

Involvement of Tissue Inhibitors of Metalloproteinases (TIMPS) During Matrix Metalloproteinase Activation

1996
Matrix metalloproteinases (MMPs), also termed “matrixins”, constitute a family of zinc metalloendopeptidases that participate in breakdown of extracellular matrix macromolecules (Woessner, 1991). These enzymes are considered to play an important role in many biological processes such as in reproduction, embryogenesis, tissue resorption, and in the ...
H, Nagase, K, Suzuki, Y, Itoh, C C, Kan, M R, Gehring, W, Huang, K, Brew   +6 more
openaire   +2 more sources

Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in kidney disease

2021
Matrix metalloproteinases (MMPs) are a group of zinc and calcium endopeptidases which cleave extracellular matrix (ECM) proteins. They are also involved in the degradation of cell surface components and regulate multiple cellular processes, cell to cell interactions, cell proliferation, and cell signaling pathways.
Oskar, Zakiyanov, Marta, Kalousová, Tomáš, Zima, Vladimír, Tesař   +3 more
openaire   +2 more sources

Engineering metalloproteinase inhibitors: tissue inhibitors of metalloproteinases or antibodies, that is the question

Current Opinion in Biotechnology
Targeting metalloproteinases (MPs) has been the center of attention for developing therapeutics due to their contribution to a wide range of diseases, including cancer, cardiovascular, neurodegenerative disease, and preterm labor. Protein-based MP inhibitors offer higher stability and selectivity, which is critical for developing efficient therapeutics
Masoud Kalantar, Gregory A Hilpert, Ethan R Mosca, Maryam Raeeszadeh-Sarmazdeh   +3 more
openaire   +2 more sources

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in colonic adenomas-adenocarcinomas

Diseases of the Colon & Rectum, 1996
Colonic adenocarcinomas evolve through a multistep process from tubular adenomas to invasive adenocarcinomas. Matrix metalloproteinases (MMPs) have been implicated in proteolysis of basement membrane for initiation of metastatic cascade.By immunocytochemical staining, hyperplastic polyps, tubular adenomas, tubovillous adenomas, villous adenomas to ...
T, Tomita, K, Iwata
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Tissue inhibitor of metalloproteinases-1 in breast cancer

Endocrine Related Cancer, 2005
Whether patients diagnosed with primary breast cancer are offered adjuvant systemic therapy following surgical removal of the tumor is based on prognosis. Prognosis is estimated in every patient using established prognostic variables. Unfortunately, when using the currently available prognostic parameters a significant proportion of patients are over ...
Würtz, Sidse Ørnbjerg, Rasmussen, Anne-Sofie Schrohl, Sørensen, Nanna Møller, Lademann, Ulrik, Christensen, Ib Jarle, Mouridsen, H., Brünner, Nils   +6 more
openaire   +3 more sources