Results 41 to 50 of about 2,104,548 (252)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Amending of fluorescence sensor signal localization in human skin by matching of the reflective index. [PDF]

, 2004
Fluorescence diagnostic techniques are notable amongst many other optical methods because they offer high sensitivity and non-invasive measurement of tissue properties.
Churmakov, D. Y., Greenhalgh, Douglas A., Meglinski, Igor V., Igor V. Meglinski, Douglas A. Greenhalgh, Dmitry Y. Churmakov   +5 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Macroscopic polarimetric discrimination and quantification of antiangiogenic effect of AGRO aptamer and GK1 peptide in a preclinical melanoma model

Scientific Reports
Histological analysis remains the gold standard for tissue diagnosis and evaluation, but it often relies on subjective visual interpretation and limited field of view areas. In this study, we present a macroscopic, wide-field Mueller polarimetric imaging
Ivan Montes-Gonzalez, Judit Bisbal-Amat, Armando Perez-Torres, Evelyn Pulido-Camarillo, Monica Canabal-Carbia, juan Campos, Irene Estevez, Angel Lizana   +7 more
doaj   +1 more source

Monte Carlo modeling of photon propagation reveals highly scattering coral tissue

Frontiers in Plant Science, 2016
Corals are very efficient at using solar radiation, with photosynthetic quantum efficiencies approaching theoretical limits. Here, we investigated potential mechanisms underlying such outstanding photosynthetic performance through extracting inherent ...
Daniel Wangpraseurt, Steven Jacques, Tracy Petrie, Michael Kühl   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Unveiling the improved targeting migration of mesenchymal stem cells with CXC chemokine receptor 3-modification using intravital NIR-II photoacoustic imaging

Journal of Nanobiotechnology, 2022
Background Therapy with genetically modified mesenchymal stem cells (MSCs) has clinical translation promise. Optimizing the targeting migratory ability of MSCs relies on accurate imaging of the distribution and extravasation kinetics of MSCs, and the ...
Yuejun Lin, Hui-chao Zhou, Ningbo Chen, Yaguang Ren, Rongkang Gao, Qiaojia Li, Yiwen Deng, Xuejiao Han, Xiaoran Zhang, Andy Peng Xiang, Bing Guo, Chengbo Liu, Jie Ren   +12 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Adipose derived tissue engineered heart valve [PDF]

, 2015
Introduction: A major challenge associated with heart valve tissue engineering is the in vitro creation of mature tissue structures compliant with native valve functionality.
Baaijens, FPT Frank, Beer, G M, Driessen - Mol, A., Hoerstrup, S., Beer, G.M., Baaijens, Frank P T, Baaijens, F.P.T., Weber, B., Hoerstrup, S P, Driessen-Mol, Anita, Frese, Laura, Frese, L., Driessen-Mol, A Anita, Weber, Benedikt, Beer, Gertrude M, Sanders, B Bart, Hoerstrup, S Simon, Sanders, Bart, Sanders, B.   +18 more
core   +2 more sources