Results 51 to 60 of about 2,104,548 (252)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Image sharpening metrics and search strategies for indirect adaptive optics [PDF]

, 2000
Adaptive optics is concerned with the correction of turbulence induced aberrations and mis-alignments in optical systems. It is an expensive and complicated technology which has been developed for astronomy and defence applications.
Doble, N., Doble, Nathan
core  

Generation of novel blue natural biomaterials from fish scales for use in cornea repair and engineering

Materials & Design
Fish scale biomaterials (FSB) were obtained from red scorpionfish (SSC), salmon (SSA), white sea bream (DS) and European carp (CC). Native FSB were preconditioned and cellularized with limbal epithelial cells, and evaluated ex vivo and in vivo.
I. Garzón, J. Muñoz-Hurtado, J. Pereira-Martínez, C. González-Gallardo, A.M. Ionescu, J.C. Cardona, M. Tejada-Casado, M.M. Pérez, J. Chato-Astrain, M. Alaminos   +9 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Optimising the NAOMI adaptive optics real-time control system [PDF]

, 2008
This thesis describes the author's research in the field of Real-Time Control (RTC) for Adaptive Optics (AO) instrumentation. The research encompasses experiences and knowledge gained working in the area of RTC on astronomical instrumentation projects ...
Goodsell, S. J., Goodsell, S J
core  

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Fluorescence suppression using wavelength modulated Raman spectroscopy in fiber-probe-based tissue analysis [PDF]

, 2012
The work was funded by CR-UK/EPSRC/MRC/DoH (England) imaging programme.In the field of biomedical optics, Raman spectroscopy is a powerful tool for probing the chemical composition of biological samples.
Ashok, Praveen Cheriyan, Herrington, C Simon, Herrington, Simon, Riches, Andrew, Ashok, Praveen C., Mazilu, Michael, Dholakia, Kishan, Balagopal, Bavishna, Praveen, Bavishna B., Riches, Andrew Clive   +9 more
core   +1 more source

Optogenetic Multiphysical Fields Coupling Model for Implantable Neuroprosthetic Probes

IEEE Access
Optogenetic-based neuroprosthetic therapies are increasingly being considered for human trials. However, the optoelectronic design of clinical-grade optogenetic-based neuroprosthetic probes still requires some thought.
Na Dong, Emily Johnson, Rolando Berlinguer-Palmini, Hongze Zhong, Fahimeh Dehkhoda, Ahmed Soltan, Konstantin Nikolic, Nir Grossman, Johannes Gausden, Richard Bailey, Anthony O'Neill, Andrew Jackson, Andrew Trevelyan, Patrick Degenaar, Xiaohan Sun   +14 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source