Streptolysin O accelerates the conversion of plasminogen to plasmin
Group A Streptococcus (GAS) is a human-specific bacterial pathogen that can exploit the plasminogen-plasmin fibrinolysis system to dismantle blood clots and facilitate its spread and survival within the human host.
Di Tang+6 more
doaj +1 more source
Differences between binding of one-chain and two-chain tissue plasminogen activators to non-cross-linked and cross-linked fibrin clots [PDF]
S. Shaukat Husain+2 more
openalex +1 more source
Brain metastasis in non‐small cell lung cancer: High‐risk factors and predictive models
Artificial intelligence (AI) can integrate of data to predict brain metastases (BM) in non‐small cell lung cancer (NSCLC). AI algorithms are employed to analyze these multifaceted datasets, enabling the identification of complex patterns and correlations that may not be apparent through traditional analytical methods.
Chen Gong+7 more
wiley +1 more source
First year of 24/7 Acute Stroke Unit. Part 2: outcome of stroke thrombolysis using telemedicine [PDF]
OBJECTIVE: To evaluate the safety and efficacy of intravenous recombinant tissue plasminogen activator (IV-rtPA) for acute ischaemic stroke through telemedicine consultation ...
Chang, C+8 more
core
Pharmacokinetic and distribution analysis of variant forms of tissue- type plasminogen activator with prolonged clearance in rat [PDF]
GR Larsen+4 more
openalex +1 more source
Chinese Guidelines for Diagnosis and Treatment of Chronic Rhinosinusitis (2024)
ABSTRACT Chronic rhinosinusitis (CRS), a complex inflammatory disease with heterogeneous pathogenesis, demands evolving evidence‐based strategies. Since the 2018 Chinese guidelines and EPOS2020, international advances in CRS immunopathology and biologics have revolutionized therapeutic approaches, particularly through phenotype–endotype classification ...
Subspecialty Group of Rhinology+4 more
wiley +1 more source
Preparation of polyethylene glycol-tissue plasminogen activator adducts that retain functional activity: characteristics and behavior in three animal species [PDF]
H Jr Berger, SV Pizzo
openalex +1 more source
Epigenetic Clock Analysis of Sex Chromosome Aneuploidies
Next‐generation epigenetic clocks indicate lower age acceleration and slower pace of aging in 47,XXY than 46,XX, 46,XY, and 47,XYY. A first‐generation clock (Skin & Blood) indicates higher age acceleration in 47,XXY and 47,XYY than 46,XY, while higher naïve CD8+ T in 47,XXY than both 46,XY and 46,XX suggests reduced immunosenescence.
Joshua Zhang+7 more
wiley +1 more source
Blood cells participate in the fibrinolytic response to tissue-type plasminogen activator [PDF]
MW Hammouda, LA Moroz
openalex +1 more source
Role for Complement C5 in Eosinophilic Inflammation of Severe Asthma
Complement activation module, particularly C5, is positively associated with eosinophilic inflammation in severe asthma cohorts. Elevated C5 expression correlates with poor lung function improvement and persistent eosinophilic inflammation. Mouse model studies confirm that C5 exacerbates eosinophilic inflammation, highlighting its potential as a ...
Cong Dong+217 more
wiley +1 more source