Results 151 to 160 of about 81,875 (260)

Neuroprotective Effects of Phenothiazines on Acute Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
For acute ischemic stroke due to large vessel occlusion, adjunctive neuroprotective therapy with mechanical thrombectomy is important; however, current treatment options are relatively limited. Phenothiazines such as chlorpromazine and promethazine (C + P) have shown potential neuroprotective effects in preclinical studies.
Qi Wang, Weili Li, Di Wu, Shuaili Xu, Xunming Ji   +4 more
wiley   +1 more source

A Multicenter, Open-Label Study to Assess the Safety of Nebulized Tissue Plasminogen Activator for the Acute Treatment of Pediatric Plastic Bronchitis: The PLATyPuS Trial. [PDF]

Pharmacotherapy
Stringer KA, Goldberg D, Chen S, Thrush P, Graham EM, Lubert A, Myers J, McLellan L, Flott T, Nasr S, Schumacher KR.   +10 more
europepmc   +1 more source

Pharmacokinetics and Neuroprotective Efficacy of Poly‐Arginine Peptide R18D in Sprague Dawley Rats Subjected to Transient Intraluminal Filament Middle Cerebral Artery Occlusion Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
The R18D peptide exhibits a favorable pharmacokinetic profile and significantly reduces infarct volume in a rat model of middle cerebral artery occlusion (MCAO) followed by reperfusion. These findings highlight the potential clinical utility of R18D as a neuroprotective therapy for stroke patients undergoing endovascular recanalization interventions ...
Bruno P. Meloni, Stuart K. Gribble, Meghan G. Thomas, Ayelet Weksler, Lena Finkelstein, Lena Fishtein, Dimitry Kovalchuk, Gilad Maximov, Avital Schauder, Keren Kigel‐Zur, Sigal Meilin   +10 more
wiley   +1 more source

Imaging efficacy and safety of low dose intraventricular tissue plasminogen activator in aneurysmal subarachnoid hemorrhage: case series. [PDF]

Acta Neurochir (Wien)
Liu C, Wroe WW, Zeineddine HA, Dawes B, Giordano M, McCabe A, Chen CJ, McBride DW, Gusdon AM, Choi HA, Blackburn SL.   +10 more
europepmc   +1 more source

VSMC phenotypic switching in thoracic aortic aneurysm at single‐cell resolution: Trajectories, regulatory circuits, and spatial niches

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
•Single‐cell/spatial multi‐omics identify four VSMC phenotypic states in TAA progression. •KLF4 as master hub (TGF‐β/TNF‐α/mechanical stress) orchestrating chromatin remodelling. •Pseudotime trajectories mapping contractile phenotypes towards osteogenic (RUNX2/SOX9) and inflammatory (TNF‐α/IL‐6) fates within spatial medial niches. •cfDNA biomarkers and
Zehua Shao, Chunguang Guo, Zhongyuan Lu, Jianyang Liu, Hao Tang, Hongwei Guo, Zhidong Zhang   +6 more
wiley   +1 more source

Tissue plasminogen activator modified thromboelastography identifies fibrinolysis resistance in dogs with immune-mediated hemolytic anemia. [PDF]

Front Vet Sci
Goggs R, Davis S, Brooks MB.
europepmc   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

Enhancing Thrombolysis Safety in Post-Acute Ischemic Stroke with Tissue Plasminogen Activator-Associated Microparticles. [PDF]

ACS Nano
Spanò R, Portioli C, Geroski T, Felici A, Palange AL, Gawne PJ, Mamberti S, Avancini G, Palomba R, Bonnard T, Moore TL, Del Sette M, Filipovic N, Vivien D, Decuzzi P.   +14 more
europepmc   +1 more source

Poor long-term fellow-eye outcomes after vitrectomy with subretinal tissue plasminogen activator for AMD-related submacular hemorrhage. [PDF]

Graefes Arch Clin Exp Ophthalmol
Fried S, Vorobichik Berar O, David D, Arazi M, Klain B, Cohen GY, Fogel Levin M, Platner E, Katz G, Hostovsky A.   +9 more
europepmc   +1 more source

Serum tissue plasminogen activator after cycling with blood flow restriction. [PDF]

Vasc Biol
Landers JB, Allen M, Oladele I, Lowe L, Ali N, Rainey J, Fletcher J, Landers K.   +7 more
europepmc   +1 more source