Results 141 to 150 of about 165,123 (342)

Streptolysin O accelerates the conversion of plasminogen to plasmin

open access: yesNature Communications
Group A Streptococcus (GAS) is a human-specific bacterial pathogen that can exploit the plasminogen-plasmin fibrinolysis system to dismantle blood clots and facilitate its spread and survival within the human host.
Di Tang   +6 more
doaj   +1 more source

Clinical Policy: Use of Intravenous Tissue Plasminogen Activator for the Management of Acute Ischemic Stroke in the Emergency Department [PDF]

open access: bronze, 2015
Michael D. Brown   +29 more
openalex   +1 more source

Long‐term remission in gout: Challenges and future opportunities

open access: yesRheumatology &Autoimmunity, EarlyView.
Prolonged hyperuricemia is a major risk factor for gout, which is now regarded as a curable disease. Awareness of the various factors that can trigger gout flares is essential for their prevention. An important determinant of treatment decisions and long‐term follow‐up is the quality of the clinician–patient relationship. The “treat‐to‐target” approach
Patapong Towiwat, Zhanguo Li
wiley   +1 more source

Decreased Production of Tissue Plasminogen Activator in Endothelial Cells From Nasal Polyps

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Introduction Previous studies have demonstrated that chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by excessive fibrin deposition which is related to impaired production of tissue plasminogen activator(t‐PA) by epithelial cells.
Qian‐Qian Zhang   +9 more
wiley   +1 more source

Role for Complement C5 in Eosinophilic Inflammation of Severe Asthma

open access: yesAllergy, EarlyView.
Complement activation module, particularly C5, is positively associated with eosinophilic inflammation in severe asthma cohorts. Elevated C5 expression correlates with poor lung function improvement and persistent eosinophilic inflammation. Mouse model studies confirm that C5 exacerbates eosinophilic inflammation, highlighting its potential as a ...
Cong Dong   +217 more
wiley   +1 more source

International Guideline on the Diagnosis and Management of Pediatric Patients With Hereditary Angioedema

open access: yesAllergy, EarlyView.
ABSTRACT Hereditary angioedema (HAE) with C1 inhibitor deficiency is a rare disease characterized by unpredictable episodes of tissue swelling (angioedema), which, in most cases, occur first under the age of 18 years, and entail a significant burden of disease not only for the patients but also for their families.
Henriette Farkas   +128 more
wiley   +1 more source

The Impact of Obesity on Durable Left Ventricular Assist Device Implantation: A Systematic Review and Meta‐Analysis

open access: yesArtificial Organs, EarlyView.
14 100 LVAD patients across 21 studies were analyzed. Findings indicated that obese LVAD recipients had lower short‐term mortality and higher risk of infection, thrombosis and right heart failure. There was no difference in long‐term survival between obese and non‐obese patients.
Hugh Jacobs   +11 more
wiley   +1 more source

Tissue Plasminogen Activator and Plasminogen Activator Inhibitor Type 1 Gene Polymorphism in Patients with Gastric Ulcer Complicated with Bleeding [PDF]

open access: bronze, 2003
Hongsoo Kim   +6 more
openalex   +1 more source

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