Results 141 to 150 of about 156,767 (359)

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

open access: yesSmall Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai   +9 more
wiley   +1 more source

Thrombolysis in Stroke Patients; Problems and Limitations [PDF]

open access: yesIranian Journal of Medical Sciences, 2010
Thrombolysis for stroke is being used in some developingcountries. This study was designed to evaluate the problems ofthrombolysis therapy in Iran. During January-July 2008, all patientswith ischemic stroke admitted to Ghaem Hospital, Mashhad,northeast ...
Kavian Ghandehari,   +7 more
doaj  

The Biomaterial and Blood Clot Complex: A Crucial Early Environment for Osteo‐Coagulo‐Immunomodulation and the Advancement of Bone Biomaterials

open access: yesSmall Structures, EarlyView.
Various properties of bone biomaterials can modulate components of the blood clot (including the fibrin network, red blood cells, platelets, and the complement system) in vivo implantation, leading to the formation of a biomaterial–blood clot complex (BBCC) significantly impacting subsequent osteoimmunomodulation.
Zongpu Han   +11 more
wiley   +1 more source

Ultrasound-targeted transfection of tissue-type plasminogen activator gene carried by albumin nanoparticles to dog myocardium to prevent thrombosis after heart mechanical valve replacement

open access: yesInternational Journal of Nanomedicine, 2012
Ji Jun, Ji Shang-Yi, Yang Jian-An, He Xia, Yang Xiao-Han, Ling Wen-Ping, Chen Xiao-LingDepartment of Pathology and Cardiovascular Surgery, Shenzhen Sun Yat-Sen Cardiovascular Hospital, Shenzhen, Guangdong, People's Republic of ChinaBackground ...
Ji J   +6 more
doaj  

First year of 24/7 Acute Stroke Unit. Part 2: outcome of stroke thrombolysis using telemedicine [PDF]

open access: yes, 2013
OBJECTIVE: To evaluate the safety and efficacy of intravenous recombinant tissue plasminogen activator (IV-rtPA) for acute ischaemic stroke through telemedicine consultation ...
Chang, C   +8 more
core  

Identification of Senomorphic miRNAs in Embryonic Progenitor and Adult Stem Cell‐Derived Extracellular Vesicles

open access: yesAging Cell, EarlyView.
A senomorphic miRNA cocktail (E5), consisting of miR‐181a‐5p, miR‐92a‐3p, miR‐21‐5p, and miR‐186‐5p, was identified from a pool of miRNAs enriched in extracellular vesicles (EVs) derived from multiple functional human stem cell types. E5 reduces senescence and SASP markers both in cell culture and in aged mice.
Tianpeng Zhang   +11 more
wiley   +1 more source

Mutant and chimeric recobinant plasminogen activatorsproduction in eukaryotic cellsand preliminary characterization [PDF]

open access: yes, 1987
Mutant urokinase-type plasminogen activator (u-PA) genes and hybrid genes between tissue-type plasminogen activator (t-PA) and u-PA have been designed to direct the synthesis of new plasminogen activators and to investigate the structure-function ...
Andre, B.   +11 more
core   +1 more source

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