Results 261 to 270 of about 83,548 (314)
Some of the next articles are maybe not open access.
Tissue Plasminogen Activator (t-PA)
Therapeutic Drug Monitoring, 1993Tissue plasminogen activator (t-PA) developed from recombinant DNA technology is a highly effective thrombolytic agent. Its main clinical application is in the treatment of acute myocardial infarction (MI), with most beneficial results occurring in patients treated early after the onset of symptoms. When t-PA was compared with other thrombolytic agents,
Jayesh Madhani +2 more
openaire +3 more sources
The Plasminogen Activator in Animal Tissue
Acta Physiologica Scandinavica, 1956Summary.1. The plasminogen activator in pig heart tissue and pig lung tissue has been isolated in soluble form and partially purified.2. The tissue activator is a fairly thermostable substance especially at acid reaction.3. The tissue activator represents a type of plasminogen activator different from the activator found in urine or produced in blood ...
Tage Astrup, Ida Sterndorff
openaire +3 more sources
The potentiating effect of platelet on plasminogen activation by tissue plasminogen activator
Thrombosis Research, 1985A new role for platelets in fibrinolysis is proposed. Platelets (euglobulin from platelet rich plasma and from human platelet extract) may potentiate plasminogen activation by tissue plasminogen activator (tPA). The potentiating activity was detected by both chromogenic substrate and fibrin plate analysis. The fibrinolysis-potentiating substance in the
F. W. Dunn +6 more
openaire +3 more sources
Differences in the activation rates of plasminogen by tissue plasminogen activator and urokinase
Thrombosis Research, 1987The activation of a native form of plasminogen (Glu-plg) by tissue plasminogen activator(t-PA) was enhanced when the plasma was clotted by the addition of thrombin or thrombin plus Ca++. Cross-linking of fibrin in the clotted plasma did not inhibit the fibrin-associated enhancement of the activation of plasminogen by t-PA.
Masaru Cho +3 more
openaire +3 more sources
Tissue Plasminogen Activator and DNase in Empyema
New England Journal of Medicine, 2011Item does not contain ...
Simons, S.O. +2 more
openaire +5 more sources
European Journal of Clinical Pharmacology, 1992
Defibrotide, a polydeoxyribonucleotide of mammalian origin, has been shown to reduce the blood level of the plasminogen activator inhibitor, and so to increase the activity of tissue plasminogen activator without any adverse effect. A randomized, double-blind, placebo-controlled study has been done in 22 patients, 14 with peripheral vascular disease, 6
VIOLI, Francesco +5 more
openaire +4 more sources
Defibrotide, a polydeoxyribonucleotide of mammalian origin, has been shown to reduce the blood level of the plasminogen activator inhibitor, and so to increase the activity of tissue plasminogen activator without any adverse effect. A randomized, double-blind, placebo-controlled study has been done in 22 patients, 14 with peripheral vascular disease, 6
VIOLI, Francesco +5 more
openaire +4 more sources
Lipoprotein(a) inhibition of plasminogen activation by tissue-type plasminogen activator
Thrombosis Research, 1990Here experimental evidence is presented demonstrating that Lp(a) inhibits the activation of Pg by the physiologic activator tissue-type plasminogen activator (t-PA) bound to fibrinogen fragments. The competitive inhibition constant, Kie, of the Lp(a) inhibition is 22 nM, or 8.6 mg/dL which corresponds to normal plasma ...
Jay M. Edelberg +2 more
openaire +3 more sources
Claims on tissue plasminogen activator
Nature, 1989A 'master' patent on a recombinant protein product has twice been overturned in British courts. The consequences may be far-reaching.
openaire +3 more sources
Kinetic studies of plasminogen activation by epithelial tissue plasminogen activator
Blood Coagulation & Fibrinolysis, 1990Initial-rate kinetic studies of the activation of plasminogen by epithelial activator were performed in the absence and in the presence of fibrinogen and CNBr-digested fibrinogen, under assay conditions similar to those described by Hoylaerts et al. (J Biol Chem, 257, 2912, 1982).
A Electricwala, R J Ling, Atkinson T
openaire +3 more sources
Studies on the kinetics of plasminogen activation by tissue plasminogen activator
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1982The steady-state rate of plasminogen activation by tissue plasminogen activator has been determined at various plasminogen concentrations. A plasmin substrate method similar to that presented by Christensen and Müllertz (Biochim. Biophys. Acta 480 (1977) 257-281) was used.
openaire +3 more sources