Results 241 to 250 of about 579,513 (302)
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Differences in the activation rates of plasminogen by tissue plasminogen activator and urokinase
Thrombosis Research, 1987The activation of a native form of plasminogen (Glu-plg) by tissue plasminogen activator(t-PA) was enhanced when the plasma was clotted by the addition of thrombin or thrombin plus Ca++. Cross-linking of fibrin in the clotted plasma did not inhibit the fibrin-associated enhancement of the activation of plasminogen by t-PA.
A, Takada, K, Shizume, M, Cho, Y, Takada
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Kinetic studies of plasminogen activation by epithelial tissue plasminogen activator
Blood Coagulation & Fibrinolysis, 1990Initial-rate kinetic studies of the activation of plasminogen by epithelial activator were performed in the absence and in the presence of fibrinogen and CNBr-digested fibrinogen, under assay conditions similar to those described by Hoylaerts et al. (J Biol Chem, 257, 2912, 1982).
A, Electricwala, R J, Ling, T, Atkinson
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European Journal of Clinical Pharmacology, 1992
Defibrotide, a polydeoxyribonucleotide of mammalian origin, has been shown to reduce the blood level of the plasminogen activator inhibitor, and so to increase the activity of tissue plasminogen activator without any adverse effect. A randomized, double-blind, placebo-controlled study has been done in 22 patients, 14 with peripheral vascular disease, 6
VIOLI, Francesco +5 more
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Defibrotide, a polydeoxyribonucleotide of mammalian origin, has been shown to reduce the blood level of the plasminogen activator inhibitor, and so to increase the activity of tissue plasminogen activator without any adverse effect. A randomized, double-blind, placebo-controlled study has been done in 22 patients, 14 with peripheral vascular disease, 6
VIOLI, Francesco +5 more
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Efficacy and safety of tissue plasminogen activator
Neurosurgery, 1987Simple aspiration to remove acute intracerebral hematomas has been thwarted by the solidity of the clot. Urokinase, a first generation fibrinolytic agent, has been used to liquefy such clots with some success. Therefore, tissue plasminogen activator (t-PA), a second generation fibrinolytic drug that may be safer and more effective, was studied to ...
H H, Kaufman +4 more
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Claims on tissue plasminogen activator
Nature, 1989A 'master' patent on a recombinant protein product has twice been overturned in British courts. The consequences may be far-reaching.
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Thrombosis Research, 1988
Glu-plasminogen (Glu-plg), Lys-plg and Val442-plg (mini-plg) were activated by urokinase (UK), streptokinase (SK) or tissue plasminogen activator (t-PA). Their activation rates were kinetically analyzed. UK activated Lys-plg with smaller Km and nearly identical Vmax as Glu-plg.
A, Takada, Y, Takada, Y, Sugawara
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Glu-plasminogen (Glu-plg), Lys-plg and Val442-plg (mini-plg) were activated by urokinase (UK), streptokinase (SK) or tissue plasminogen activator (t-PA). Their activation rates were kinetically analyzed. UK activated Lys-plg with smaller Km and nearly identical Vmax as Glu-plg.
A, Takada, Y, Takada, Y, Sugawara
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Neurology, 2007
Tissue-type plasminogen activator (tPA) is a serine protease that cleaves plasminogen into active plasmin. In plasma, the primary function of plasmin is the digestion of fibrin, and therefore, tPA is used as a thrombolytic agent for acute treatment of ischemic stroke.
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Tissue-type plasminogen activator (tPA) is a serine protease that cleaves plasminogen into active plasmin. In plasma, the primary function of plasmin is the digestion of fibrin, and therefore, tPA is used as a thrombolytic agent for acute treatment of ischemic stroke.
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Content of Tissue Activator of Plasminogen in Monkey Tissues
Thrombosis and Haemostasis, 1957SummaryThe content of the tissue activator of plasminogen in various organs from monkey is generally lower than in the corresponding human organs and approaches the concentration in the organs of other animals.
H R, ROBERTS, T, ASTRUP
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Regulation of Tissue Plasminogen Activator Expression
Annual Review of Physiology, 1989Widespread interest in the biology of the fibrinolytic system has developed with the recognition of the role of intravascular thrombosis in the pathogene sis of human disease. The therapeutic application of thrombolytic agents is a result of the rapid evolution of our understanding of the biochemistry and physiological importance of this system.
R D, Gerard, R S, Meidell
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Tissue Plasminogen Activator and the Corneal Endothelium
American Journal of Ophthalmology, 1989• There is a potential risk of bacterial or fungal contamination of the initial preparation, which could then result in contamination of each of the individual doses. It is essential, therefore, that the tissue plasminogen activator be reconstituted under strict aseptic conditions in a sterile hood.
M L, McDermott +3 more
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