Results 221 to 230 of about 81,875 (260)
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Regulation of Tissue Plasminogen Activator Expression
Annual Review of Physiology, 1989Widespread interest in the biology of the fibrinolytic system has developed with the recognition of the role of intravascular thrombosis in the pathogene sis of human disease. The therapeutic application of thrombolytic agents is a result of the rapid evolution of our understanding of the biochemistry and physiological importance of this system.
R D, Gerard, R S, Meidell
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Tissue Plasminogen Activator and the Corneal Endothelium
American Journal of Ophthalmology, 1989• There is a potential risk of bacterial or fungal contamination of the initial preparation, which could then result in contamination of each of the individual doses. It is essential, therefore, that the tissue plasminogen activator be reconstituted under strict aseptic conditions in a sterile hood.
M L, McDermott +3 more
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Tissue Plasminogen Activator Activity in Prostatic Cancer
European Urology, 198419 patients with carcinoma of the prostate and 6 controls with hyperplasia of the prostate, have been investigated to elucidate the relationship between tumor fibrinolytic activity, the degree of malignancy, tumor stage and metastatic spread. Significantly (p less than 0.001) higher tissue plasminogen activator activities were found in metastatic ...
A, Köller +3 more
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Tissue Plasminogen Activator (t-PA)
Therapeutic Drug Monitoring, 1993Tissue plasminogen activator (t-PA) developed from recombinant DNA technology is a highly effective thrombolytic agent. Its main clinical application is in the treatment of acute myocardial infarction (MI), with most beneficial results occurring in patients treated early after the onset of symptoms. When t-PA was compared with other thrombolytic agents,
J, Madhani, H, Movsowitz, M N, Kotler
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Ontogenesis of Tissue Plasminogen Activator in the Human
Thrombosis and Haemostasis, 1971SummaryThe ontogenesis of tissue plasminogen activator in various tissues was studied in 10 embryos and 58 foetuses with a histochemical method.The first appearance of activator activity was seen in a 4-weeks old embryo. At 8-9 weeks it was seen in the eye, meninges, heart, lungs, kidney and vena cava. In the foetal heart high activity was found in the
B, Astedt, M, Pandolfi
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Tissue plasminogen activators in breast cancer
Thrombosis Research, 1987Increased levels of tissue fibrinolytic activity have been detected in some malignant tumours and they have been implicated in metastatic spread. We have investigated tissue plasminogen activator (tPA) and urokinase (UK) in 26 breast carcinomas and 13 benign breast biopsies.
G T, Layer +6 more
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Plasminogen activators and inhibitors in peritoneal tissue
APMIS, 1997Serosal trauma elicits an inflammatory response which leads to the deposition of fibrin at injured sites, the residuals of which appear to be essential in excessive tissue repair and formation of intraabdominal adhesions. Local plasminogen activity may modulate this early phase of tissue repair.
L, Holmdahl +3 more
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Effectors of the activation of human [Glu1]plasminogen by human tissue plasminogen activator
Biochemistry, 1988The activation of human [Glu1]plasminogen [( Glu1]Pg) by human recombinant (rec) two-chain tissue plasminogen activator (t-PA) is inhibited by Cl-, at physiological concentrations, and stimulated by epsilon-aminocaproic acid (EACA), as well as fibrin(ogen).
T, Urano +3 more
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Plasminogen Activators, Tissue Degradation, and Cancer
1985Publisher Summary This chapter discusses the role of plasminogen activators in various biological processes. In specific, it describes two types of plasminogen activators—namely, the urokinase-type plasminogen activator (u-PA) and the tissue-type plasminogen activator (t-PA), which are essentially different gene products.
K, Danø +5 more
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Plasminogen and Tissue Plasminogen Activator Interact with Antithrombin III
Thrombosis Research, 2000Human antithrombin III was demonstrated to bind plasminogen specifically in a time and concentration-dependent manner. The above binding was also confirmed using ligand western blot assays. The interaction of plasminogen was significantly (>90%) inhibited by lysine, indicating the involvement of kringles in binding antithrombin III.
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