Results 221 to 230 of about 2,071,373 (281)

Neutrophil migration participates in the side effect of recombinant human tissue plasminogen activator. [PDF]

CNS Neurosci Ther
Huang Y, Han Z, Shen T, Zheng Y, Yang Z, Fan J, Wang R, Yan F, Tao Z, Luo Y, Liu P.   +10 more
europepmc   +1 more source

Tissue Plasminogen Activator or Perfluoropropane for Submacular Hemorrhage in Age-Related Macular Degeneration: A Factorial Randomized Clinical Trial.

JAMA Ophthalmol
Murphy GSP, Saleh A, Ayis S, Cheema MR, Mehta A, Steel DH, Membrey L, Costen M, Jackson TL.   +8 more
europepmc   +1 more source

The Neurotoxicity of Tissue Plasminogen Activator? [PDF]

Journal of Cerebral Blood Flow and Metabolism, 2004
Tissue plasminogen activator (tPA), a fibrin specific activator for the conversion of plasminogen to plasmin, stimulates thrombolysis and rescues ischemic brain by restoring blood flow. However, emerging data suggests that under some conditions, both tPA and plasmin, which are broad spectrum protease enzymes, are potentially ...
Alastair Buchan, Eng H Lo
exaly   +4 more sources

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Tissue Activator of Plasminogen

Nature, 1964
SINCE Astrup and Permin1 reported that animal tissue cells contain an activator of plasminogen, various authors have confirmed their results, and comparisons of the activator content of different human2 and animal tissues3,4 have been published. Most authors have used whole tissue or aqueous tissue extracts and have estimated activity by the fibrin ...
C H, LACK, S Y, ALI
openaire   +2 more sources

Tissue Plasminogen Activator

New England Journal of Medicine, 1988
TISSUE plasminogen activator (t-PA) is a naturally occurring protein that catalyzes the conversion of the inactive proenzyme plasminogen into the active serine protease plasmin.
John A. Oates, Alastair J.J. Wood, Joseph Loscalzo, Eugene Braunwald   +3 more
openaire   +2 more sources

Plasminogen activation by tissue plasminogen activator in the presence of platelets

Thrombosis Research, 1988
Platelets were found to provide a surface for activation of plasminogen by the tissue-type plasminogen activator (t-PA) at an optimum concentration and to potentiate the generation of plasmin by the amidolytic method, fibrin lysis time and fibrin plate method.
K, Deguchi, S, Shirakawa
openaire   +2 more sources

The Plasminogen Activator in Animal Tissue

Acta Physiologica Scandinavica, 1956
Summary.1. The plasminogen activator in pig heart tissue and pig lung tissue has been isolated in soluble form and partially purified.2. The tissue activator is a fairly thermostable substance especially at acid reaction.3. The tissue activator represents a type of plasminogen activator different from the activator found in urine or produced in blood ...
T, ASTRUP, I, STERNDORFF
openaire   +2 more sources

Tissue-Type Plasminogen Activator

Haemostasis, 2009
Tissue-type plasminogen activator (t-PA) is a serine protease with a molecular weight of about 70,000. It activates plasminogen to plasmin by cleavage of the Arg 560-Val 561 peptide bond. Kinetic analysis showed that the activation obeys Michaelis-Menten kinetics and that the presence of fibrin strikingly enhances the activation rate.
H R, Lijnen, D, Collen
openaire   +2 more sources

The potentiating effect of platelet on plasminogen activation by tissue plasminogen activator

Thrombosis Research, 1985
A new role for platelets in fibrinolysis is proposed. Platelets (euglobulin from platelet rich plasma and from human platelet extract) may potentiate plasminogen activation by tissue plasminogen activator (tPA). The potentiating activity was detected by both chromogenic substrate and fibrin plate analysis. The fibrinolysis-potentiating substance in the
K, Deguchi, S, Murashima, S, Shirakawa, C, Soria, J, Soria, F, Dunn, G, Tobelem   +6 more
openaire   +2 more sources