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HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Tissue Plasminogen Activator or Perfluoropropane for Submacular Hemorrhage in Age-Related Macular Degeneration: A Factorial Randomized Clinical Trial.

JAMA Ophthalmol
Murphy GSP, Saleh A, Ayis S, Cheema MR, Mehta A, Steel DH, Membrey L, Costen M, Jackson TL.   +8 more
europepmc   +1 more source

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Studies on the kinetics of plasminogen activation by tissue plasminogen activator

BBA - Proteins and Proteomics, 1982
The steady-state rate of plasminogen activation by tissue plasminogen activator has been determined at various plasminogen concentrations. A plasmin substrate method similar to that presented by Christensen and Müllertz (Biochim. Biophys. Acta 480 (1977) 257-281) was used.
Mats Rånby
exaly   +3 more sources

Lipoprotein(a) inhibition of plasminogen activation by tissue-type plasminogen activator

Thrombosis Research, 1990
Here experimental evidence is presented demonstrating that Lp(a) inhibits the activation of Pg by the physiologic activator tissue-type plasminogen activator (t-PA) bound to fibrinogen fragments. The competitive inhibition constant, Kie, of the Lp(a) inhibition is 22 nM, or 8.6 mg/dL which corresponds to normal plasma ...
Jay M Edelberg, Salvatore V Pizzo
exaly   +3 more sources

Tissue Plasminogen Activator

New England Journal of Medicine, 1988
TISSUE plasminogen activator (t-PA) is a naturally occurring protein that catalyzes the conversion of the inactive proenzyme plasminogen into the active serine protease plasmin.
John A. Oates, Alastair J.J. Wood, Joseph Loscalzo, Eugene Braunwald   +3 more
openaire   +2 more sources

Tissue Activator of Plasminogen

Nature, 1964
SINCE Astrup and Permin1 reported that animal tissue cells contain an activator of plasminogen, various authors have confirmed their results, and comparisons of the activator content of different human2 and animal tissues3,4 have been published. Most authors have used whole tissue or aqueous tissue extracts and have estimated activity by the fibrin ...
C H, LACK, S Y, ALI
openaire   +2 more sources

Activation of Bovine Plasminogen by the Plasminogen Activator in Animal Tissue

Thrombosis and Haemostasis, 1960
Summary1. The activation of bovine plasminogen by means of the plasminogen activator from pig heart tissue has been studied on heated fibrin and on casein.2. Small, but varying, amounts of activator can be extracted from crude activator powder during the experiment and interfere therefore with estimations on normal, plasminogen containing fibrin.3. The
T, ABE, T, ASTRUP
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Plasminogen activation by tissue plasminogen activator in the presence of platelets

Thrombosis Research, 1988
Platelets were found to provide a surface for activation of plasminogen by the tissue-type plasminogen activator (t-PA) at an optimum concentration and to potentiate the generation of plasmin by the amidolytic method, fibrin lysis time and fibrin plate method.
K, Deguchi, S, Shirakawa
openaire   +2 more sources

Tissue-Type Plasminogen Activator

Haemostasis, 2009
Tissue-type plasminogen activator (t-PA) is a serine protease with a molecular weight of about 70,000. It activates plasminogen to plasmin by cleavage of the Arg 560-Val 561 peptide bond. Kinetic analysis showed that the activation obeys Michaelis-Menten kinetics and that the presence of fibrin strikingly enhances the activation rate.
H R, Lijnen, D, Collen
openaire   +2 more sources