Results 191 to 200 of about 579,513 (302)

Predictive value of serum homocysteine and potassium ion for short-term prognosis of patients with acute cerebral infarction following intravenous thrombolysis with recombinant tissue plasminogen activator. [PDF]

Thromb J
Pang L, Sun Y, He M, Xu B.
europepmc   +1 more source

Colchicine as an Adjunctive Therapy to Improve Ischemic Stroke Reperfusion Outcomes in Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
In a tMCAO mouse model of ischemia–reperfusion, colchicine administered at reperfusion suppresses neutrophil activation by inhibiting F‐actin polymerization. Thereby, it improves cerebral blood flow by limiting NET formation and intravascular fibrin(ogen) deposition and preserves BBB integrity by attenuating cerebrovascular inflammation and ...
Danni Wang, Yuwen Xiu, Mengxuan Shi, Yingjie Wang, Di Zhou, Mitchell D. Kilgore, Lauren Dumont, Thin Yadanar Sein, Yinghua Jiang, Nicole Kazour, Ning Liu, Aaron S. Dumont, Qiang Liu, Xiaoying Wang   +13 more
wiley   +1 more source

A pilot randomised, open label controlled trial comparing safety and efficacy of pleural irrigation with normal saline versus intrapleural tissue plasminogen activator and DNase (fibrinolytic therapy) in pleural infection. [PDF]

BMC Pulm Med
Rozi SNM, Jailaini MFM, Azmel AA, Ismail NAN, Fuad NFN, Zainal IA, Ghan SL, Shah SA, Rahim MJC, Hamid MFA.   +9 more
europepmc   +1 more source

Comprehensive Evaluation of YJ‐2 as a PAD4 Inhibitor in Alleviating Ischemic Brain Injury: From NETs‐Induced Neurotoxicity to In Vivo Neuroprotection

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
The novel PAD4 inhibitor YJ‐2 potently suppresses neutrophil extracellular trap (NETs) formation. In a rat model of ischemic stroke, YJ‐2 treatment significantly reduces cerebral infarct volume and improves neurological function, demonstrating its therapeutic potential.
Yijiang Jia, Ayijiang Taledaohan, Kai Wang, Maer Maer Tuohan, Rong Chen, Liujia Chan, Haoyu Shen, Di Zhu, Yuji Wang   +8 more
wiley   +1 more source

Transcranial Doppler ultrasound evaluation of vascular recanalization following tissue plasminogen activator intravenous thrombolysis in acute middle cerebral artery occlusion: A case report and literature review. [PDF]

SAGE Open Med Case Rep
Lv S, Liu R, Sun J, Liu H, Bian J, Ding C, Guo X.   +6 more
europepmc   +1 more source

Inflammaging: Experimental Insights and Translational Advances

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Inflammaging is a chronic, low‐grade, sterile inflammation associated with aging that contributes to age‐related diseases and functional decline. Recent research suggests that targeting inflammaging through senolytics, metabolic modulators, microbiome‐based interventions, and lifestyle modifications may help improve healthspan, reduce chronic disease ...
Andrea Cossarizza
wiley   +1 more source

Outcomes of Emergent Stenting with Antiplatelet Therapy in Patients with Large Vessel Occlusion Stroke with or without Intravenous Tissue Plasminogen Activator. [PDF]

J Neuroendovasc Ther
Teranishi K, Fujiwara S, Sunohara T, Koyanagi M, Goto M, Takeda J, Fukumitsu R, Fukui N, Takano Y, Nakajima K, Naramoto Y, Yamamoto Y, Nishii R, Kawade S, Takamatsu T, Tokuda M, Tomita H, Yoshimoto M, Ohara N, Sakai N, Ohta T.   +20 more
europepmc   +1 more source

Research on the Mechanism of Natural Products Acting on Chronic Obstructive Pulmonary Disease

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This figure illustrates that approximately 80 natural compounds exert therapeutic effects against chronic obstructive pulmonary disease by targeting pathological mechanisms such as airway inflammation, oxidative stress, airway remodeling, mucus hypersecretion, emphysema, protease–antiprotease imbalance, apoptosis, and autophagy.
Shuna Wei, Xiaoju Liu
wiley   +1 more source

Recurrence associated with 2-year visual acuity after subretinal tissue plasminogen activator for submacular hemorrhage in neovascular age-related macular degeneration. [PDF]

Jpn J Ophthalmol
Tanaka M, Miyata M, Hata M, Ooto S, Tamura H, Kido A, Ueda-Arakawa N, Miyake M, Takahashi A, Muraoka Y, Tsujikawa A.   +10 more
europepmc   +1 more source

Astrocyte Mechanobiology: Linking Biomechanical Forces to Biochemical Signaling in the Central Nervous System

Glia, Volume 74, Issue 7, July 2026.
Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat, Alima Ahmed, Mariano Viapiano, Preethi S. Ganapathy   +3 more
wiley   +1 more source