Results 231 to 240 of about 2,071,373 (281)

Differences in the activation rates of plasminogen by tissue plasminogen activator and urokinase

Thrombosis Research, 1987
The activation of a native form of plasminogen (Glu-plg) by tissue plasminogen activator(t-PA) was enhanced when the plasma was clotted by the addition of thrombin or thrombin plus Ca++. Cross-linking of fibrin in the clotted plasma did not inhibit the fibrin-associated enhancement of the activation of plasminogen by t-PA.
A, Takada, K, Shizume, M, Cho, Y, Takada
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Lipoprotein(a) inhibition of plasminogen activation by tissue-type plasminogen activator

Thrombosis Research, 1990
Here experimental evidence is presented demonstrating that Lp(a) inhibits the activation of Pg by the physiologic activator tissue-type plasminogen activator (t-PA) bound to fibrinogen fragments. The competitive inhibition constant, Kie, of the Lp(a) inhibition is 22 nM, or 8.6 mg/dL which corresponds to normal plasma ...
J M, Edelberg, M, Gonzalez-Gronow, S V, Pizzo   +2 more
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Studies on the kinetics of plasminogen activation by tissue plasminogen activator

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1982
The steady-state rate of plasminogen activation by tissue plasminogen activator has been determined at various plasminogen concentrations. A plasmin substrate method similar to that presented by Christensen and Müllertz (Biochim. Biophys. Acta 480 (1977) 257-281) was used.
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Kinetic studies of plasminogen activation by epithelial tissue plasminogen activator

Blood Coagulation & Fibrinolysis, 1990
Initial-rate kinetic studies of the activation of plasminogen by epithelial activator were performed in the absence and in the presence of fibrinogen and CNBr-digested fibrinogen, under assay conditions similar to those described by Hoylaerts et al. (J Biol Chem, 257, 2912, 1982).
A, Electricwala, R J, Ling, T, Atkinson
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Efficacy and safety of tissue plasminogen activator

Neurosurgery, 1987
Simple aspiration to remove acute intracerebral hematomas has been thwarted by the solidity of the clot. Urokinase, a first generation fibrinolytic agent, has been used to liquefy such clots with some success. Therefore, tissue plasminogen activator (t-PA), a second generation fibrinolytic drug that may be safer and more effective, was studied to ...
H H, Kaufman, S, Schochet, W, Koss, J, Herschberger, D, Bernstein   +4 more
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Claims on tissue plasminogen activator

Nature, 1989
A 'master' patent on a recombinant protein product has twice been overturned in British courts. The consequences may be far-reaching.
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Activation of Val442-plasminogen (mini-plasminogen) by urokinase, streptokinase and tissue plasminogen activator

Thrombosis Research, 1988
Glu-plasminogen (Glu-plg), Lys-plg and Val442-plg (mini-plg) were activated by urokinase (UK), streptokinase (SK) or tissue plasminogen activator (t-PA). Their activation rates were kinetically analyzed. UK activated Lys-plg with smaller Km and nearly identical Vmax as Glu-plg.
A, Takada, Y, Takada, Y, Sugawara
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Tissue plasminogen activator

Neurology, 2007
Tissue-type plasminogen activator (tPA) is a serine protease that cleaves plasminogen into active plasmin. In plasma, the primary function of plasmin is the digestion of fibrin, and therefore, tPA is used as a thrombolytic agent for acute treatment of ischemic stroke.
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Plasminogen activators and inhibitors in peritoneal tissue

APMIS, 1997
Serosal trauma elicits an inflammatory response which leads to the deposition of fibrin at injured sites, the residuals of which appear to be essential in excessive tissue repair and formation of intraabdominal adhesions. Local plasminogen activity may modulate this early phase of tissue repair.
L, Holmdahl, M, Falkenberg, M L, Ivarsson, B, Risberg   +3 more
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Tissue plasminogen activator inhibitor in the epidermis

British Journal of Dermatology, 1985
The presence of a tissue plasminogen activator inhibitor in the epidermis was investigated. A partially purified tissue plasminogen activator from a Bowes melanoma cell line medium was used as a tissue plasminogen activator. Extracts of epidermis dissolved in a 10 mM phosphate buffer, pH 7.0, were found to contain a tissue plasminogen activator ...
K, Hashimoto, I, Katayama, K, Nishioka
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