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Tissue Plasminogen Activator (tPA)
2015Tissue plasminogen activator (tPA) is used in the setting of acute ischemic stroke. tPA is also utilized for several additional thrombolytic indications, including acute MI, pulmonary embolism, and central venous catheter occlusion.
Juan E. Small +2 more
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Efficacy and safety of tissue plasminogen activator
Neurosurgery, 1987Simple aspiration to remove acute intracerebral hematomas has been thwarted by the solidity of the clot. Urokinase, a first generation fibrinolytic agent, has been used to liquefy such clots with some success. Therefore, tissue plasminogen activator (t-PA), a second generation fibrinolytic drug that may be safer and more effective, was studied to ...
David Bernstein +4 more
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Content of Tissue Activator of Plasminogen in Monkey Tissues
Thrombosis and Haemostasis, 1957SummaryThe content of the tissue activator of plasminogen in various organs from monkey is generally lower than in the corresponding human organs and approaches the concentration in the organs of other animals.
H. R Roberts, Tage Astrup
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Thrombosis Research, 1988
Glu-plasminogen (Glu-plg), Lys-plg and Val442-plg (mini-plg) were activated by urokinase (UK), streptokinase (SK) or tissue plasminogen activator (t-PA). Their activation rates were kinetically analyzed. UK activated Lys-plg with smaller Km and nearly identical Vmax as Glu-plg.
Yoshiaki Sugawara +2 more
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Glu-plasminogen (Glu-plg), Lys-plg and Val442-plg (mini-plg) were activated by urokinase (UK), streptokinase (SK) or tissue plasminogen activator (t-PA). Their activation rates were kinetically analyzed. UK activated Lys-plg with smaller Km and nearly identical Vmax as Glu-plg.
Yoshiaki Sugawara +2 more
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Plasminogen activators and inhibitors in peritoneal tissue
APMIS, 1997Serosal trauma elicits an inflammatory response which leads to the deposition of fibrin at injured sites, the residuals of which appear to be essential in excessive tissue repair and formation of intraabdominal adhesions. Local plasminogen activity may modulate this early phase of tissue repair.
Mårten Falkenberg +3 more
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Tissue Plasminogen Activator and the Corneal Endothelium
American Journal of Ophthalmology, 1989• There is a potential risk of bacterial or fungal contamination of the initial preparation, which could then result in contamination of each of the individual doses. It is essential, therefore, that the tissue plasminogen activator be reconstituted under strict aseptic conditions in a sterile hood.
Mark L. McDermott +3 more
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Regulation of Tissue Plasminogen Activator Expression
Annual Review of Physiology, 1989Widespread interest in the biology of the fibrinolytic system has developed with the recognition of the role of intravascular thrombosis in the pathogene sis of human disease. The therapeutic application of thrombolytic agents is a result of the rapid evolution of our understanding of the biochemistry and physiological importance of this system.
R S Meidell, Robert D. Gerard
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Neurology, 2007
Tissue-type plasminogen activator (tPA) is a serine protease that cleaves plasminogen into active plasmin. In plasma, the primary function of plasmin is the digestion of fibrin, and therefore, tPA is used as a thrombolytic agent for acute treatment of ischemic stroke.
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Tissue-type plasminogen activator (tPA) is a serine protease that cleaves plasminogen into active plasmin. In plasma, the primary function of plasmin is the digestion of fibrin, and therefore, tPA is used as a thrombolytic agent for acute treatment of ischemic stroke.
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Ontogenesis of Tissue Plasminogen Activator in the Human
Thrombosis and Haemostasis, 1971SummaryThe ontogenesis of tissue plasminogen activator in various tissues was studied in 10 embryos and 58 foetuses with a histochemical method.The first appearance of activator activity was seen in a 4-weeks old embryo. At 8-9 weeks it was seen in the eye, meninges, heart, lungs, kidney and vena cava. In the foetal heart high activity was found in the
Astedt B, Pandolfi M
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Tissue plasminogen activators in breast cancer
Thrombosis Research, 1987Increased levels of tissue fibrinolytic activity have been detected in some malignant tumours and they have been implicated in metastatic spread. We have investigated tissue plasminogen activator (tPA) and urokinase (UK) in 26 breast carcinomas and 13 benign breast biopsies.
M. Pattison +12 more
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