Results 291 to 300 of about 165,123 (342)

Tissue Plasminogen Activator (t-PA)

Therapeutic Drug Monitoring, 1993
Tissue plasminogen activator (t-PA) developed from recombinant DNA technology is a highly effective thrombolytic agent. Its main clinical application is in the treatment of acute myocardial infarction (MI), with most beneficial results occurring in patients treated early after the onset of symptoms. When t-PA was compared with other thrombolytic agents,
J, Madhani, H, Movsowitz, M N, Kotler
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Glycated Proteins Modulate Tissue–Plasminogen Activator-Catalyzed Plasminogen Activation

Biochemical and Biophysical Research Communications, 1997
Plasminogen activation by tissue-plasminogen activator (t-PA) is accelerated by the presence of a macromolecular surface, which acts as a template that brings enzyme and substrate in close proximity. Modification of lysine residues, which are important for this template function, occurs in diabetic patients as a consequence of glycation of proteins. In
I W, Bobbink, W L, Tekelenburg, J J, Sixma, H C, de Boer, J D, Banga, P G, de Groot   +5 more
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Tissue plasminogen activator

Neurology, 2007
Tissue-type plasminogen activator (tPA) is a serine protease that cleaves plasminogen into active plasmin. In plasma, the primary function of plasmin is the digestion of fibrin, and therefore, tPA is used as a thrombolytic agent for acute treatment of ischemic stroke.
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Peroxynitrite Inactivates Tissue Plasminogen Activator

Anesthesia & Analgesia, 2004
Tissue plasminogen activator (tPA) has a prominent role in physiological fibrinolysis in vivo. Thrombosis has been associated with clinical scenarios (e.g., atherosclerotic disease) known to involve local decreases in tPA activity with concomitant formation of reactive nitrogen species such as peroxynitrite (OONO(-)), a molecule formed from nitric ...
Vance G, Nielsen, John P, Crow, Fen, Zhou, Dale A, Parks   +3 more
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Kinetic studies of plasminogen activation by epithelial tissue plasminogen activator

Blood Coagulation & Fibrinolysis, 1990
Initial-rate kinetic studies of the activation of plasminogen by epithelial activator were performed in the absence and in the presence of fibrinogen and CNBr-digested fibrinogen, under assay conditions similar to those described by Hoylaerts et al. (J Biol Chem, 257, 2912, 1982).
A, Electricwala, R J, Ling, T, Atkinson
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Claims on tissue plasminogen activator

Nature, 1989
A 'master' patent on a recombinant protein product has twice been overturned in British courts. The consequences may be far-reaching.
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Tissue Plasminogen Activator Activity in Prostatic Cancer

European Urology, 1984
19 patients with carcinoma of the prostate and 6 controls with hyperplasia of the prostate, have been investigated to elucidate the relationship between tumor fibrinolytic activity, the degree of malignancy, tumor stage and metastatic spread. Significantly (p less than 0.001) higher tissue plasminogen activator activities were found in metastatic ...
A, Köller, J, Kirchheimer, H, Pflüger, B R, Binder   +3 more
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Effect of oral defibrotide on tissue-plasminogen activator and tissue-plasminogen activator inhibitor balance

European Journal of Clinical Pharmacology, 1992
Defibrotide, a polydeoxyribonucleotide of mammalian origin, has been shown to reduce the blood level of the plasminogen activator inhibitor, and so to increase the activity of tissue plasminogen activator without any adverse effect. A randomized, double-blind, placebo-controlled study has been done in 22 patients, 14 with peripheral vascular disease, 6
VIOLI, Francesco, FERRO, Domenico, C. Quintarelli, BASILI, Stefania, F. Balsano, SALIOLA, Mirella   +5 more
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Tissue Plasminogen Activator (tPA)

2015
Tissue plasminogen activator (tPA) is used in the setting of acute ischemic stroke. tPA is also utilized for several additional thrombolytic indications, including acute MI, pulmonary embolism, and central venous catheter occlusion.
Evan Watkins, Juan E. Small, Daniel Thomas Ginat   +2 more
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[Tissue-type plasminogen activator].

Medicina (Florence, Italy), 1990
Tissue-type plasminogen activator (t-PA) is a serine protease that converts a zymogen plasminogen into an active serine protease, namely, plasmin. Plasmin is the proteolytic enzyme that degrades fibrin. In the absence of fibrin, e.g., in circulating plasma, t-PA activates plasminogen at a very slow rate.
F M, Turazza, M, Pogna
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