Results 61 to 70 of about 156,767 (359)

Effect of dsRNA on Mesangial Cell Synthesis of Plasminogen Activator Inhibitor Type 1 and Tissue Plasminogen Activator [PDF]

, 2009
Background/Aims: Viral infections are a major problem worldwide and many of them are complicated by virally induced glomerulonephritides. Progression of kidney disease to renal failure is mainly attributed to the development of renal fibrosis ...
Merkle, Monika, Ribeiro, Andrea, Roeder, Maximilian, Sauter, Matthias, Wörnle, Markus   +4 more
core   +1 more source

Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis

Advanced Science, EarlyView.
In this study, a mechanical biomimetic nanocomposite is developed, guided by photoacoustic imaging, to achieve highly efficient and safe thrombolysis through the synergistic effects of photothermal therapy and pharmacological intervention. Most notably, the nanoparticle improves the microenvironment of arterial thrombi, marked by high shear stress and ...
Ying Li, Qi Xiang, Yan Zhang, Fuxue Luo, Yunfang Wu, Haitao Ran, Yang Cao   +6 more
wiley   +1 more source

Needle detection and localisation for robot‐assisted subretinal injection using deep learning

CAAI Transactions on Intelligence Technology, EarlyView., 2023
Abstract Subretinal injection is a complicated task for retinal surgeons to operate manually. In this paper we demonstrate a robust framework for needle detection and localisation in robot‐assisted subretinal injection using microscope‐integrated Optical Coherence Tomography with deep learning.
Mingchuan Zhou, Xiangyu Guo, Matthias Grimm, Elias Lochner, Zhongliang Jiang, Abouzar Eslami, Juan Ye, Nassir Navab, Alois Knoll, Mohammad Ali Nasseri   +9 more
wiley   +1 more source

SOME FIBRINOLYTIC PARAMETERS IN CORONARY ARTERY DISEASE PATIENTS: FOCUS ON UNSTABLE ANGINA SUBGROUPS

Східноукраїнський медичний журнал, 2021
Background and aim. Unstable angina is classified into new-onset, progressive, and angina at rest. Though hemostasis plays a crucial role in the pathogenesis of coronary artery disease, including unstable angina, limited data exist regarding ...
Y. V. Tyravska, O. M. Bondarchuk, N. G. Raksha, V. G. Lizogub, O. M. Savchuk   +4 more
doaj   +1 more source

Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis [PDF]

, 2003
Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes.
Besch, R., Braungart, E., Degitz, K., Douwes, K., Flaig, M. J., Magdolen, V., Probst, C., Sander, C. A., Schuh, T., Wosikowski, K.   +9 more
core   +1 more source

Colorectal Cancer Cells–Derived Exosomal PIK3CA Mutation DNA Promotes Tumor Metastasis by Activating Fibroblast and Affecting Tumor Metastatic Microenvironment

Advanced Science, EarlyView.
PIK3CAH1047R DNA in colorectal cancer (CRC) cell‐derived exosomes can be delivered into recipient fibroblasts, where it is transcribed and translated, leading to the activation of fibroblasts into cancer‐associated fibroblasts, which secrete elevated levels of IL6. The simultaneous detection and targeting of PIK3CAH1047R mutation and IL6 may serve as a
Rui Wang, Wanming Li, Yuqiong Lv, Wei Ba, Ying Jiang, Xiaoshuai Li, Jin Fang   +6 more
wiley   +1 more source

Plasminogen activator inhibitor 1 and gestational diabetes: the causal relationship

Diabetology & Metabolic Syndrome, 2022
Plasminogen activator inhibitor 1 (PAI-1) also known as serpin E1 or endothelial plasminogen activator inhibitor, is produced from endothelial cells and adipose tissue.
Gaber El-Saber Batiha, Hayder M. Al-kuraishy, Thabat J. Al-Maiahy, Ali K. Al-Buhadily, Hebatallah M. Saad, Ali I. Al-Gareeb, Jesus Simal-Gandara   +6 more
doaj   +1 more source

Dose de-escalation of intrapleural tissue plasminogen activator therapy for pleural infection. The alteplase dose assessment for Pleural infection Therapy project [PDF]

, 2017
Rationale: Intrapleural therapy with a combination of tissue plasminogen activator (tPA) 10 mg and DNase 5 mg administered twice daily has been shown in randomized and open-label studies to successfully manage over 90% of patients with pleural infection ...
Bintcliffe, Oliver, Blyth, Kevin G., De Fonseka, Duneesha, Edey, Anthony, Lee, Y. C. Gary, Martin, Geoffrey, Maskell, Nick, Piccolo, Francesco, Popowicz, Natalia, Smith, Nicola A., Wong, Donny   +10 more
core   +1 more source

Tissue plasminogen activator: why the backlash?

Journal of the American College of Cardiology, 1989
In recent months since the approval of intravenous thrombolytic agents in the United States, recombinant tissue plasminogen activator (rt-PA) has been under fire in many peer review medical journal articles (l-4). At issue is whether rt-PA, an expensive, elegant product of the molecular biology revolution, is really better than streptokinase, an ...
Robert M. Califf, Eric J. Topol
openaire   +3 more sources

DNase I‐Mediated Chemotactic Nanoparticles for NETs Targeting and Microenvironment Remodeling Treatment of Acute Ischemic Stroke

Advanced Science, EarlyView.
The neutrophil extracellular traps (NETs) play an important role in reperfusion injury in ischemic stroke. Here, considering the unique vascular localization of NETs, a DNase I‐mediated NETs‐targeting nanoparticle is developed to integrate the catalytic and chemotactic functions of DNase I and achieve the synergistic regulation of the internal and ...
Tongyu Zhang, Peixin Liu, Wenru Shen, Chao Li, Zhenhao Zhao, Yuxing Wu, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source