Results 81 to 90 of about 599,368 (371)

Strategies Used by Hospitals to Improve Speed of Tissue-Type Plasminogen Activator Treatment in Acute Ischemic Stroke

Stroke, 2014
Background and Purpose— The benefits of intravenous tissue-type plasminogen activator in acute ischemic stroke are time dependent, and several strategies have been reported to be associated with more rapid door-to-needle (DTN) times.
Y. Xian, Eric E. Smith, Xin Zhao, E. Peterson, Daiwai M. Olson, Adrian F. Hernandez, Deepak L. Bhatt, J. Saver, L. Schwamm, G. Fonarow   +9 more
semanticscholar   +1 more source

A Dual‐Layer Hydrogel Barrier Integrating Bio‐Adhesive and Anti‐Adhesive Properties Prevents Postoperative Abdominal Adhesions

Advanced Healthcare Materials, EarlyView.
A new dual‐layer hydrogel barrier for preventing postoperative abdominal adhesions is developed. The inner layer, consisting of polyethyleneimine (PEI) and thioctic acid (TA), enhanced adhesion to moist tissues. The outer layer combines zwitterionic, thermoresponsive hyaluronic acid with anti‐inflammatory epigallocatechin gallate (EGCG) and forms a ...
Mena Asha Krishnan, Olawale A. Alimi, Mitchell Kuss, Tiffany N Razabdouski, Erika A Eksioglu, Bin Duan, Bo Liu   +6 more
wiley   +1 more source

Kinetic Redox Shotgun Proteomics Reveals Specific Lipopolysaccharide Effects on Intestinal Epithelial Cells, Mitigated by a Mn Superoxide Dismutase Mimic

Angewandte Chemie, EarlyView.
Proteomics and redoxomics are efficient to quantify the effects of bacterial lipopolysaccharide in intestinal epithelial cells (HT29) at the proteome and at the Cys‐redoxome levels. Oxidative stress is the initial trigger of LPS leading to inflammation.
Martha Zoumpoulaki, Giovanni Chiappetta, Jean Bouvet, Namita‐Raju John, Gabrielle Schanne, Pauline Gehan, Samuel Diebolt, Shakir Shakir, Elodie Quévrain, Emilie Mathieu, Sylvie Demignot, Philippe Seksik, Nicolas Delsuc, Joelle Vinh, Clotilde Policar   +14 more
wiley   +2 more sources

The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans [PDF]

, 2017
The neurovascular unit provides a dynamic interface between the circulation and central nervous system. Disruption of neurovascular integrity occurs in numerous brain pathologies including neurotrauma and ischaemic stroke. Tissue plasminogen activator is
Beckham, Simone, Cops, Elisa J., Daglas, Maria, Freeman, Roxann, Galle, Adam, Lawrence, Daniel A., Madani, Rime, McLean, Catriona, Medcalf, Robert L., Morganti-Kossmann, Cristina, Rosenfeld, Jeffrey V., Sales, Eunice, Samson, Andre L., Sashindranath, Maithili, Su, Enming J., Vassalli, Jean-Dominique   +15 more
core  

Tissue plasminogen activator-based clot busting: Controlled delivery approaches. [PDF]

, 2014
Cardiovascular diseases are the leading cause of death worldwide. Thrombosis, the formation of blood clot (thrombus) in the circulatory system obstructing the blood flow, is one of the main causes behind various ischemic arterial syndromes such as ...
El-Sherbiny, IM, Elkholi, IE, Yacoub, MH
core   +1 more source

Engineering the Immune Response to Biomaterials

Advanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi   +12 more
wiley   +1 more source

Isolation of rat hepatoma cell variants selectively resistant to dexamethasone inhibition of plasminogen activator [PDF]

, 1979
Glucocorticoids induce several phenotypic changes in rat hepatoma cells in tissue culture, including the inhibition of plasminogen activator activity.
Gelehrter, Thomas D., Seifert, Sarah Carlson   +1 more
core   +1 more source

Inhibiting the Histone Demethylase Kdm4a Restrains Cardiac Fibrosis After Myocardial Infarction by Promoting Autophagy in Premature Senescent Fibroblasts

Advanced Science, EarlyView.
Kdm4a downregulation restrains excessive cardiac interstitial fibrosis and remodeling by depressing the premature senescence of fibroblasts in the advanced stage after MI but does not affect early ventricular rupture. It verified that Kdm4a downregulation promotes autophagy in premature senescent fibroblasts by increasing the H3K9m3 modification of the
Ming Jin, Chuling Li, Zhaoyi Wu, Zhenquan Tang, Jingfang Xie, Guoquan Wei, Zhiwen Yang, Senlin Huang, Yijin Chen, Xinzhong Li, Yanmei Chen, Wangjun Liao, Yulin Liao, Guojun Chen, Hao Zheng, Jianping Bin   +15 more
wiley   +1 more source

Tissue plasminogen activator and plasminogen activator inhibitor 1 contribute to sonic hedgehog-induced in vitro cerebral angiogenesis. [PDF]

PLoS ONE, 2012
The molecular mechanisms underlying cerebral angiogenesis have not been fully investigated. Using primary mouse brain endothelial cells (MBECs) and a capillary-like tube formation assay, we investigated whether the sonic hedgehog (Shh) signaling pathway ...
Hua Teng, Michael Chopp, Ann Hozeska-Solgot, Lihong Shen, Mei Lu, Clark Tang, Zheng Gang Zhang   +6 more
doaj   +1 more source

SOME FIBRINOLYTIC PARAMETERS IN CORONARY ARTERY DISEASE PATIENTS: FOCUS ON UNSTABLE ANGINA SUBGROUPS

Східноукраїнський медичний журнал, 2021
Background and aim. Unstable angina is classified into new-onset, progressive, and angina at rest. Though hemostasis plays a crucial role in the pathogenesis of coronary artery disease, including unstable angina, limited data exist regarding ...
Y. V. Tyravska, O. M. Bondarchuk, N. G. Raksha, V. G. Lizogub, O. M. Savchuk   +4 more
doaj   +1 more source