Results 51 to 60 of about 130,799 (295)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering

Bioactive Materials, 2022
The application of scaffolding materials is believed to hold enormous potential for tissue regeneration. Despite the widespread application and rapid advance of several tissue-engineered scaffolds such as natural and synthetic polymer-based scaffolds ...
Xuewei Zhang, Xi Chen, Hua Hong, Rubei Hu, Jiashang Liu, Changsheng Liu   +5 more
doaj   +1 more source

Biomaterial scaffolds for tissue engineering

Frontiers in Bioscience, 2013
Reconstruction and regeneration of new tissues are challenges facing scientists, technologists and clinicians. This review describes strategies of selection and design of biomaterials having significant impact on various possible synthesis routes for scaffold fabrication.
Sophie C. Cox, Kajal K. Mallick
openaire   +2 more sources

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

Dynamically adaptive scaffolds for cartilage tissue engineering

MedComm – Biomaterials and Applications, 2023
Although cartilage regeneration is a continuously changing, complex process, most studies on cartilage tissue regeneration have focused on specific stages, thereby promoting regeneration in only a limited period rather than over the entire repair process.
Yachen Peng, Yaling Zhuang, Yanbo Zhang, Jianlin Zuo, Jianxun Ding   +4 more
doaj   +1 more source

Different Species of Marine Sponges Diverge in Osteogenic Potential When Therapeutically Applied as Natural Scaffolds for Bone Regeneration in Rats

Journal of Functional Biomaterials, 2023
A highly porous structure, and an inorganic (biosilica) and collagen-like organic content (spongin) makes marine sponges potential candidates to be used as natural scaffolds in bone tissue engineering.
Cíntia P. G. Santos, João P. S. Prado, Kelly R. Fernandes, Hueliton W. Kido, Bianca P. Dorileo, Julia R. Parisi, Jonas A. Silva, Matheus A. Cruz, Márcio R. Custódio, Ana C. M. Rennó, Renata N. Granito   +10 more
doaj   +1 more source

Scaffolds for Dental Pulp Tissue Engineering [PDF]

Advances in Dental Research, 2011
For tissue engineering strategies, the choice of an appropriate scaffold is the first and certainly a crucial step. A vast variety of biomaterials is available: natural or synthetic polymers, extracellular matrix, self-assembling systems, hydrogels, or bioceramics. Each material offers a unique chemistry, composition and structure, degradation profile,
Galler, Kerstin M., D’Souza, R. N., Hartgerink, J. D., Schmalz, G.   +3 more
openaire   +3 more sources

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Nanotechnology Biomimetic Cartilage Regenerative Scaffolds

Archives of Plastic Surgery, 2014
Cartilage has a limited regenerative capacity. Faced with the clinical challenge of reconstruction of cartilage defects, the field of cartilage engineering has evolved. This article reviews current concepts and strategies in cartilage engineering with an
Erh-Hsuin Lim, Jose Paulo Sardinha, Simon Myers   +2 more
doaj   +1 more source

Improving Infection Resistance in Tissue Engineered Scaffolds for Tensile Applications Using Vancomycin‐Embedded Melt Electrowritten Scaffolds

Macromolecular Materials and Engineering, 2023
It is important to consider mechanical, biological, and antibacterial properties of scaffolds when used for tissue engineering applications. This study presents a method to create complex “wavy” architecture polycaprolactone (PCL) scaffolds toward the ...
Asha Mathew, Brenna L. Devlin, Dilpreet Singh, Naomi C. Paxton, Maria A. Woodruff   +4 more
doaj   +1 more source