Results 71 to 80 of about 1,964,988 (291)

Self-assembling peptide-enriched electrospun polycaprolactone scaffolds promote the h-osteoblast adhesion and modulate differentiation-associated gene expression [PDF]

, 2012
Electrospun polycaprolactone (PCL) is able to support the adhesion and growth of h-osteoblasts and to delay their degradation rate to a greater extent with respect to other polyesters. The drawbacks linked to its employment in regenerative medicine arise
V. Samouillan, Brun, Paola, Castagliuolo, Ignazio, Brun P, Iucci, Giovanna, Brunelli K, Delaunay, Florian, Roso, Martina, Dettin, Monica, Danesin, Roberta, Samouillan, Valérie, G. Iucci, Delaunay F, Ghezzo, Francesca, Samouillan V, Ghezzo F, Castagliuolo I, F. Delaunay, Dettin M., Roso M, Modesti M, Modesti, Michele, Danesin R, Brunelli, Katya   +23 more
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Selective laser sintering of hydroxyapatite reinforced polyethylene composites for bioactive implants and tissue scaffold development [PDF]

, 2006
Selective laser sintering (SLS) has been investigated for the production of bioactive implants and tissue scaffolds using composites of high-density polyethylene (HDPE) reinforced with hydroxyapatite (HA) with the aim of achieving the rapid manufacturing
Savalani, M.M., Harris, R.A., Y. Zhang (67313), Russell Harris (1250157), Tanner, K.E., Hao, L., L. Hao (3944387), M.M. Savalani (7201490), Zhang, Y.   +8 more
core   +1 more source

Enhancing 3D scaffold performance for bone tissue engineering: A comprehensive review of modification and functionalization strategies

Journal of Science: Advanced Materials and Devices
Bone tissue engineering holds promise for addressing bone injuries by using biomaterial-based 3D scaffolds. The efficacy of these scaffolds is paramount, relying heavily on their ability to interact with cells and facilitate tissue regeneration.
M. Selim, Hamouda M. Mousa, Muhammad Umar Aslam Khan, Gamal T. Abdel-Jaber, Nabisab Mujawar Mubarak, Ahmed Barhoum, Abdulaziz Al-Anazi, Abdalla Abdal-hay   +7 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Healthy but not osteoarthritic human meniscus-derived matrix scaffolds promote meniscus repair

Frontiers in Bioengineering and Biotechnology
Meniscus tissue is commonly injured due to sports-related injuries and age-related degeneration and approximately 50% of individuals with a meniscus tear will develop post-traumatic osteoarthritis (PTOA).
Saman Firoozi, Jon C. Ley, Dawn A. D. Chasse, David E. Attarian, Samuel S. Wellman, Annunziato Amendola, Amy L. McNulty, Amy L. McNulty, Amy L. McNulty   +8 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Functionally gradient tissue scaffold design and deposition path planning for bio-additive processes [PDF]

, 2013
A layer-based tissue scaffold is designed with heterogeneous internal architecture. The proposed layer-based design uses a bi-layer pattern of radial and spiral layer consecutively to generate functionally gradient porosity following the geometry of the ...
Khoda, AKM Bashirul, Koç, Bahattin, Özbolat, İbrahim T.   +2 more
core   +1 more source