Results 51 to 60 of about 127,780 (264)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Biological properties of solid free form designed ceramic scaffolds with BMP-2: in vitro and in vivo evaluation. [PDF]

PLoS ONE, 2012
Porous ceramic scaffolds are widely studied in the tissue engineering field due to their potential in medical applications as bone substitutes or as bone-filling materials.
Ander Abarrategi, Carolina Moreno-Vicente, Francisco Javier Martínez-Vázquez, Ana Civantos, Viviana Ramos, José Vicente Sanz-Casado, Ramón Martínez-Corriá, Fidel Hugo Perera, Francisca Mulero, Pedro Miranda, José Luís López-Lacomba   +10 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Nanotechnology Biomimetic Cartilage Regenerative Scaffolds

Archives of Plastic Surgery, 2014
Cartilage has a limited regenerative capacity. Faced with the clinical challenge of reconstruction of cartilage defects, the field of cartilage engineering has evolved. This article reviews current concepts and strategies in cartilage engineering with an
Erh-Hsuin Lim, Jose Paulo Sardinha, Simon Myers   +2 more
doaj   +1 more source

Multiphasic Scaffolds for Periodontal Tissue Engineering [PDF]

Journal of Dental Research, 2014
For a successful clinical outcome, periodontal regeneration requires the coordinated response of multiple soft and hard tissues (periodontal ligament, gingiva, cementum, and bone) during the wound-healing process. Tissue-engineered constructs for regeneration of the periodontium must be of a complex 3-dimensional shape and adequate size and demonstrate
Ivanovski, S, Vaquette, C, Gronthos, S, Hutmacher, DW, Bartold, PM   +4 more
openaire   +5 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Three-dimensional analysis of micro- and nanostructure of biomaterials and cells by method of scanning probe nanotomography

Вестник трансплантологии и искусственных органов, 2018
Aim: to perform a three-dimensional analysis of micro- and nanosctucture and quantitative morphological parameters of alginate spherical microcarriers and porous regenerated silk macrocarriers modifi ed by microparticles of decellularized rat liver matrix
A. E. Efimov, O. I. Agapova, L. A. Safonova, M. M. Bobrova, I. I. Agapov   +4 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Enhancing 3D scaffold performance for bone tissue engineering: A comprehensive review of modification and functionalization strategies

Journal of Science: Advanced Materials and Devices
Bone tissue engineering holds promise for addressing bone injuries by using biomaterial-based 3D scaffolds. The efficacy of these scaffolds is paramount, relying heavily on their ability to interact with cells and facilitate tissue regeneration.
M. Selim, Hamouda M. Mousa, Muhammad Umar Aslam Khan, Gamal T. Abdel-Jaber, Nabisab Mujawar Mubarak, Ahmed Barhoum, Abdulaziz Al-Anazi, Abdalla Abdal-hay   +7 more
doaj   +1 more source