Results 51 to 60 of about 126,895 (262)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Chitosan/hydroxyapatite scaffolds for tissue engineering manufacturing method effect comparison

Revista Facultad de Ingeniería Universidad de Antioquia, 2015
The regeneration of bone is one of the main challenges of modern medicine because many diseases including trauma and tumor can cause bone defects.
Diana Marcela Escobar-Sierra, Johan Martins, Claudia Patricia Ossa-Orozco   +2 more
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Polyfunctional Scaffolds for Tissue Engineering

Journal of Biomechanical Science and Engineering, 2006
Three-dimensional porous scaffolds play an important role for tissue engineering. The recent developments of porous scaffolds and their preparation methods, especially those developed by our group, are summarized in this review.
Tetsuya TATEISHI, Guoping CHEN, Takashi USHIDA   +2 more
doaj   +1 more source

Improving Infection Resistance in Tissue Engineered Scaffolds for Tensile Applications Using Vancomycin‐Embedded Melt Electrowritten Scaffolds

Macromolecular Materials and Engineering, 2023
It is important to consider mechanical, biological, and antibacterial properties of scaffolds when used for tissue engineering applications. This study presents a method to create complex “wavy” architecture polycaprolactone (PCL) scaffolds toward the ...
Asha Mathew, Brenna L. Devlin, Dilpreet Singh, Naomi C. Paxton, Maria A. Woodruff   +4 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Photothermal nanomaterials-based scaffolds for tissue regeneration and cancer therapy

Medicine in Novel Technology and Devices
Recently, photothermal therapy (PTT) has been considered a promising method for cancer treatment with fewer serious side effects compared to conventional radiation, chemotherapy and surgical resection.
Kuldeep Rajpoot
doaj   +1 more source

Dynamically adaptive scaffolds for cartilage tissue engineering

MedComm – Biomaterials and Applications, 2023
Although cartilage regeneration is a continuously changing, complex process, most studies on cartilage tissue regeneration have focused on specific stages, thereby promoting regeneration in only a limited period rather than over the entire repair process.
Yachen Peng, Yaling Zhuang, Yanbo Zhang, Jianlin Zuo, Jianxun Ding   +4 more
doaj   +1 more source