Results 1 to 10 of about 2,574,116 (304)

Exosomes derived from stem cells of human deciduous exfoliated teeth inhibit angiogenesis in vivo and in vitro via the transfer of miR-100-5p and miR-1246

Stem Cell Research & Therapy, 2022
Background Anti-angiogenic therapy has been shown to be a promising strategy for anti-tumor treatment. Increasing evidence indicates that tumor angiogenesis is affected by exosomes that are secreted by mesenchymal stem cells (MSCs), but whether exosomes ...
Panpan Liu, Qun Zhang, Jun Mi, Shuangshuang Wang, Qiuping Xu, Dexuan Zhuang, Wenqian Chen, Chang Liu, Liwei Zhang, Jing Guo, Xunwei Wu   +10 more
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Phenformin suppresses angiogenesis through the regulation of exosomal microRNA-1246 and microRNA-205 levels derived from oral squamous cell carcinoma cells

Frontiers in Oncology, 2022
Exosomes secreted by cancer cells are important components in the tumor microenvironment, enabling cancer cells to communicate with each other and with noncancerous cells to play important roles in tumor progression and metastasis.
Dexuan Zhuang, Shuangshuang Wang, Guanyi Liu, Guanyi Liu, Panpan Liu, Panpan Liu, Huiting Deng, Jianfeng Sun, Chang Liu, Xue Leng, Qun Zhang, Fuxiang Bai, Jun Mi, Xunwei Wu, Xunwei Wu, Xunwei Wu   +15 more
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Exosomes Derived From Hypoxia-Conditioned Stem Cells of Human Deciduous Exfoliated Teeth Enhance Angiogenesis via the Transfer of let-7f-5p and miR-210-3p

Frontiers in Cell and Developmental Biology, 2022
Physiological root resorption of deciduous teeth is a normal phenomenon. How the angiogenesis process is regulated to provide adequate levels of oxygen and nutrients in hypoxic conditions when the dental pulp tissue is reduced at the stage of root ...
Panpan Liu, Panpan Liu, Lihong Qin, Chang Liu, Jun Mi, Qun Zhang, Shuangshuang Wang, Dexuan Zhuang, Qiuping Xu, Qiuping Xu, Wenqian Chen, Wenqian Chen, Jing Guo, Jing Guo, Jing Guo, Jing Guo, Xunwei Wu, Xunwei Wu, Xunwei Wu   +18 more
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Autophagy of umbilical cord mesenchymal stem cells induced by rapamycin conduces to pro-angiogenic function of the conditioned medium

Biochemistry and Biophysics Reports, 2023
Angiogenesis is critical for wound healing and tissue repair. Umbilical cord mesenchymal stem cells (UCMSCs)-conditioned medium has certain actions to promote angiogenesis, and is expected for wound healing and tissue repair.
Wenya Wang, Xiao Li, Chaochu Cui, Guotian Yin, Wenjie Ren, Xianwei Wang   +5 more
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CUL4B Upregulates RUNX2 to Promote the Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Epigenetically Repressing the Expression of miR-320c and miR-372/373-3p

Frontiers in Cell and Developmental Biology, 2022
Mesenchymal stem cells (MSCs) within the periodontal ligament (PDL), termed periodontal ligament stem cells (PDLSCs), have a self-renewing capability and a multidirectional differentiation potential.
Jun Mi, Jun Mi, Shuangshuang Wang, Panpan Liu, Panpan Liu, Chang Liu, Dexuan Zhuang, Xue Leng, Qun Zhang, Fuxiang Bai, Qiang Feng, Xunwei Wu, Xunwei Wu, Xunwei Wu   +13 more
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Early-stage bilayer tissue-engineered skin substitute formed by adult skin progenitor cells produces an improved skin structure in vivo

Stem Cell Research & Therapy, 2020
Background In recent years, significant progress has been made in developing highly complex tissue-engineered skin substitutes (TESSs) for wound healing. However, the lack of skin appendages, such as hair follicles and sweat glands, and the time required,
Qun Zhang, Jie Wen, Chang Liu, Chuan Ma, Fuxiang Bai, Xue Leng, Zhihong Chen, Zhiwei Xie, Jun Mi, Xunwei Wu   +9 more
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Phenformin Down-Regulates c-Myc Expression to Suppress the Expression of Pro-Inflammatory Cytokines in Keratinocytes

Cells, 2022
The treatment of many skin inflammation diseases, such as psoriasis and atopic dermatitis, is still a challenge and inflammation plays important roles in multiple stages of skin tumor development, including initiation, promotion and metastasis ...
Guanyi Liu, Dingyang Li, Liwei Zhang, Qiuping Xu, Dexuan Zhuang, Panpan Liu, Ling Hu, Huiting Deng, Jianfeng Sun, Shuangshuang Wang, Bin Zheng, Jing Guo, Xunwei Wu   +12 more
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Constructing a cell microenvironment with biomaterial scaffolds for stem cell therapy

Stem Cell Research & Therapy, 2021
Stem cell therapy is widely recognized as a promising strategy for exerting therapeutic effects after injury in degenerative diseases. However, limitations such as low cell retention and survival rates after transplantation exist in clinical applications.
Xiaotong Zhao, Qiong Li, Zhikun Guo, Zongjin Li   +3 more
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Development of a Metaphyseal Non-Union Model in the Osteoporotic Rat Femur

Bioengineering, 2023
The aim of this current study was to establish a metaphyseal femoral non-union model in osteoporotic rats by comparing a power tool versus a manual tool for fracture creation. Twelve adult female Sprague Dawley rats were ovariectomized (OVX) and received
Amelie Deluca, Andrea Wagner, Bettina Faustini, Nadja Weissenbacher, Christian Deininger, Florian Wichlas, Herbert Tempfer, Ernst J. Mueller, Andreas Traweger   +8 more
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Tendon vasculature in health and disease.

Frontiers in Physiology, 2015
Tendons represent a bradytrophic tissue which is poorly vascularized and, compared to bone or skin, heal poorly. Usually, a vascularized connective scar tissue with inferior functional properties forms at the injury site.
Herbert eTempfer, Herbert eTempfer, Andreas eTraweger, Andreas eTraweger   +3 more
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