Results 41 to 50 of about 2,574,116 (304)

Advanced therapeutic scaffolds of biomimetic periosteum for functional bone regeneration

Journal of Nanobiotechnology
Treating chronic bone injuries and defects remains a significant challenge in orthopedic medicine, impacting patient mobility, recovery time, and healthcare costs.
Archita Gupta, Kyung Wook Kim, Amal George Kurian, Shreyas Kumar Jain, Suparna Bhattacharya, Rajendra K. Singh, Hae-Won Kim   +6 more
doaj   +1 more source

Up-Regulation of Activating Transcription Factor 3 in Human Fibroblasts Inhibits Melanoma Cell Growth and Migration Through a Paracrine Pathway

Frontiers in Oncology, 2020
The treatment of melanoma has remained a difficult challenge. Targeting the tumor stroma has recently attracted attention for developing novel strategies for melanoma therapy.
Tingjian Zu, Tingjian Zu, Jie Wen, Jie Wen, Lin Xu, Lin Xu, Lin Xu, Hui Li, Jun Mi, Jun Mi, Hui Li, Cord Brakebusch, David E. Fisher, Xunwei Wu, Xunwei Wu, Xunwei Wu   +15 more
doaj   +1 more source

Force-Induced Nitric Oxide Promotes Osteogenic Activity during Orthodontic Tooth Movement in Mice

Stem Cells International, 2022
Objectives. The aim of this study was to investigate the effect of nitric oxide (NO) on orthodontic tooth movement and the regulatory effect on bone formation. Design.
Yuqing Sun, Jingfei Fu, Feiran Lin, Shengnan Li, Juan Du, Yi Liu, Yuxing Bai   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A carbazole compound, 9-ethyl-9H-carbazole-3-carbaldehyde, plays an antitumor function through reactivation of the p53 pathway in human melanoma cells

Cell Death and Disease, 2021
p53, the major tumor suppressor, is frequently mutated in many cancers, and up to 84% of human melanomas harbor wild-type p53, which is considered to be an ideal target for melanoma therapy.
Jie Wen, Wenqian Chen, Baoxiang Zhao, Qiuping Xu, Chang Liu, Qun Zhang, Zhiwei Xie, Yonggan Yan, Jing Guo, Jun Huang, Junying Miao, Xunwei Wu   +11 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Sprayable nanozyme hydrogel epigenetically remodels inflammation for diabetic wound regeneration

Nature Communications
Chronic diabetic wounds present a critical clinical challenge due to persistent inflammation and compromised healing. Here, we report a sprayable nanozyme hydrogel that epigenetically remodels macrophages (Mφ) to suppress inflammation and coordinate ...
Amal George Kurian, Jeong-Hui Park, Shanika Karunasagara, Archita Gupta, Shreyas Kumar Jain, Tanza Baby, Ueon Sang Shin, Sak Lee, Buuvee Bayarkhangai, Rajendra K. Singh, Jung-Hwan Lee, Kam W. Leong, Hae-Won Kim   +12 more
doaj   +1 more source

Inhibition of Calcineurin/NFAT Signaling Blocks Oncogenic H-Ras Induced Autophagy in Primary Human Keratinocytes

Frontiers in Cell and Developmental Biology, 2021
Mutations of H-Ras, a member of the RAS family, are preferentially found in cutaneous squamous cell carcinomas (SCCs). H-Ras has been reported to induce autophagy, which plays an essential role in tissue homeostasis in multiple types of cancer cells and ...
Shuangshuang Wang, Hua Qian, Liwei Zhang, Panpan Liu, Panpan Liu, Dexuan Zhuang, Qun Zhang, Fuxiang Bai, Zhihong Wang, Yonggan Yan, Jing Guo, Jing Guo, Jun Huang, Xunwei Wu, Xunwei Wu   +14 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Polymer Scaffolds for Bone Tissue Regeneration

, 2011
The term “tissue engineering” refers to methods and techniques used to improve the regeneration of human cells and tissues, including the manipulation of natural and synthetic materials which provide both the structural integrity and the biochemical ...
GENTA, IDA, CONTI, BICE, COLONNA, CLAUDIA, DORATI, ROSSELLA   +3 more
core   +1 more source