Results 41 to 50 of about 449,011 (317)

The Use of Finite Element Analyses to Design and Fabricate Three-Dimensional Scaffolds for Skeletal Tissue Engineering [PDF]

, 2017
Computational modeling has been increasingly applied to the field of tissue engineering and regenerative medicine. Where in early days computational models were used to better understand the biomechanical requirements of targeted tissues to be ...
Moroni, Lorenzo, Moroni, Lorenzo; id_orcid, Jeroen Rouwkema, Clemens. A. van Blitterswijk, Rouwkema, Jeroen, Lorenzo Moroni, Hendrikson, W.J., Hendrikson, Wim J, van Blitterswijk, Clemens A, Wim. J. Hendrikson, van Blitterswijk, Clemens   +10 more
core   +1 more source

Inhibition of Calcineurin/NFAT Signaling Blocks Oncogenic H-Ras Induced Autophagy in Primary Human Keratinocytes

Frontiers in Cell and Developmental Biology, 2021
Mutations of H-Ras, a member of the RAS family, are preferentially found in cutaneous squamous cell carcinomas (SCCs). H-Ras has been reported to induce autophagy, which plays an essential role in tissue homeostasis in multiple types of cancer cells and ...
Shuangshuang Wang, Hua Qian, Liwei Zhang, Panpan Liu, Panpan Liu, Dexuan Zhuang, Qun Zhang, Fuxiang Bai, Zhihong Wang, Yonggan Yan, Jing Guo, Jing Guo, Jun Huang, Xunwei Wu, Xunwei Wu   +14 more
doaj   +1 more source

Nanotechnology in the Regeneration of Complex Tissues [PDF]

Bone and Tissue Regeneration Insights, 2014
Modern medicine faces a growing crisis as demand for organ transplantations continues to far outstrip supply. By stimulating the body's own repair mechanisms, regenerative medicine aims to reduce demand for organs, while the closely related field of tissue engineering promises to deliver “of-the-self” organs grown from patients' own stem cells to ...
openaire   +3 more sources

Pre-aggregation of scalp progenitor dermal and epidermal stem cells activates the WNT pathway and promotes hair follicle formation in in vitro and in vivo systems

Stem Cell Research & Therapy, 2019
Background Billions of dollars are invested annually by pharmaceutical companies in search of new options for treating hair loss conditions; nevertheless, the challenge remains.
Yiqun Su, Jie Wen, Junrong Zhu, Zhiwei Xie, Chang Liu, Chuan Ma, Qun Zhang, Xin Xu, Xunwei Wu   +8 more
doaj   +1 more source

High-fat and high-glucose microenvironment decreases Runx2 and TAZ expression and inhibits bone regeneration in the mouse

Journal of Orthopaedic Surgery and Research, 2019
Background Type 2 diabetes mellitus (T2DM) and hyperlipidemia are negatively related to bone regeneration. The aim of this study was to evaluate the effect of high-fat and high-glucose microenvironment on bone regeneration and to detect the expression of
Xuan Wu, Yunpeng Zhang, Yixiao Xing, Bin Zhao, Cong Zhou, Yong Wen, Xin Xu   +6 more
doaj   +1 more source

Genipin and insulin combined treatment improves implant osseointegration in type 2 diabetic rats

Journal of Orthopaedic Surgery and Research, 2021
Background Type 2 diabetes mellitus (T2DM) has a harmful effect on the stability and osseointegration of dental implants. T2DM induces mitochondrial damage by inhibiting AMPK signaling, resulting in oxidative stress and poor osteogenesis in the peri ...
Jiajia Zhang, Ya-nan Wang, Tingting Jia, Haiyun Huang, Dongjiao Zhang, Xin Xu   +5 more
doaj   +1 more source

Is There a Governing Role of Osteocytes in Bone Tissue Regeneration?

, 2020
Purpose of Review: Bone regeneration plays an important role in contemporary clinical treatment. Bone tissue engineering should result in successful bone regeneration to restore congenital or acquired bone defects in the human skeleton.
Bravenboer, N., Wu, G., Cao, W., Cao, Wei, ten Bruggenkate, Christiaan M., Bravenboer, Nathalie, Klein-Nulend, J., Schulten, Engelbert A.J.M., ten Bruggenkate, C.M., Klein-Nulend, Jenneke, Helder, M.N., Schulten, E.A.J.M., Helder, Marco N., Jin, J., Wu, Gang, Jin, Jianfeng   +15 more
core   +1 more source

In situ guided tissue regeneration in musculoskeletal diseases and aging

, 2022
S.725-735In situ guided tissue regeneration, also addressed as in situ tissue engineering or endogenous regeneration, has a great potential for population-wide ""minimal invasive"" applications.
Ebert, R., Nöth, U., Walles, Heike, Meinel, L., Groll, J., Jakob, F., Docheva, D., Rudert, M., Schieker, M.   +8 more
core   +1 more source

Trends in Double Networks as Bioprintable and Injectable Hydrogel Scaffolds for Tissue Regeneration [PDF]

, 2021
Additive manufacturing and injection are essential tools in the rapidly developing field of personalized medicine and are particularly promising for applications in regenerative medicine.
Aldana, A.A., PITET, Louis, Lorenzo Moroni, Baker, M.B., Aldana, Ana, Houben, S., Matthew B. Baker, Moroni, Lorenzo, Louis M. Pitet, Moroni, L.; id_orcid, Sofie Houben, Baker, Matthew, Baker, M.B.; id_orcid, Ana A. Aldana, Moroni, L., Pitet, L.M., HOUBEN, Sofie   +16 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source