Results 51 to 60 of about 449,011 (317)

Advanced therapeutic scaffolds of biomimetic periosteum for functional bone regeneration

Journal of Nanobiotechnology
Treating chronic bone injuries and defects remains a significant challenge in orthopedic medicine, impacting patient mobility, recovery time, and healthcare costs.
Archita Gupta, Kyung Wook Kim, Amal George Kurian, Shreyas Kumar Jain, Suparna Bhattacharya, Rajendra K. Singh, Hae-Won Kim   +6 more
doaj   +1 more source

Tissue Engineering for Meniscus Regeneration [PDF]

, 2010
Objective: Meniscus regeneration is limited, moreover, loss of meniscal tissue leads to osteoarthritis. A new biomaterial, consisting of hyaluronic acid and polycaprolactone was applied as a meniscus substitute device in a study in sheep. Methods: 24 sheep received a total medial meniscal replacement.
KON, ELIZAVETA, Delcogliano M, FILARDO, GIUSEPPE, Peretti G, Di Martino A, MARCACCI, MAURILIO   +5 more
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An in situ tissue engineering scaffold with growth factors combining angiogenesis and osteoimmunomodulatory functions for advanced periodontal bone regeneration

Journal of Nanobiotechnology, 2021
Background The regeneration of periodontal bone defect remains a vital clinical challenge. To date, numerous biomaterials have been applied in this field. However, the immune response and vascularity in defect areas may be key factors that are overlooked
Tian Ding, Wenyan Kang, Jianhua Li, Lu Yu, Shaohua Ge   +4 more
doaj   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Nano-Micro Letters
Highlights Nanozyme-based approaches to produce therapeutic hydrogels. Enzymatic mechanisms and multifunctional roles of nanozyme-engineered hydrogels for skin therapy.
Amal George Kurian, Rajendra K. Singh, Varsha Sagar, Jung-Hwan Lee, Hae-Won Kim   +4 more
doaj   +1 more source

The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells

Stem Cell Research & Therapy, 2020
Background Periodontal ligament stem cells (PDLSCs) have many applications in the field of cytotherapy, tissue engineering, and regenerative medicine.
Xiaoyu Li, Bowen Zhang, Hong Wang, Xiaolu Zhao, Zijie Zhang, Gang Ding, Fulan Wei   +6 more
doaj   +1 more source

MicroRNAs Regulating Hippo-YAP Signaling in Liver Cancer

Biomedicines, 2021
Liver cancer is one of the most common cancers worldwide, and its prevalence and mortality rate are increasing due to the lack of biomarkers and effective treatments.
Na-Hyun Lee, So Jung Kim, Jeongeun Hyun
doaj   +1 more source

Protein transduction: A novel tool for tissue regeneration [PDF]

, 2002
Tissue regeneration in humans is limited and excludes vitals organs like heart and brain. Transformation experiments with oncogenes like T antigen have shown that retrodifferentiation of the respective cells is possible but hard to control. To bypass the
Cardoso, M. C., Cardoso, M. Cristina, Leonhardt, Heinrich, Leonhardt, H., Cardoso, M.C.   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source