Results 51 to 60 of about 2,574,116 (304)

Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Nano-Micro Letters
Highlights Nanozyme-based approaches to produce therapeutic hydrogels. Enzymatic mechanisms and multifunctional roles of nanozyme-engineered hydrogels for skin therapy.
Amal George Kurian, Rajendra K. Singh, Varsha Sagar, Jung-Hwan Lee, Hae-Won Kim   +4 more
doaj   +1 more source

Genipin and insulin combined treatment improves implant osseointegration in type 2 diabetic rats

Journal of Orthopaedic Surgery and Research, 2021
Background Type 2 diabetes mellitus (T2DM) has a harmful effect on the stability and osseointegration of dental implants. T2DM induces mitochondrial damage by inhibiting AMPK signaling, resulting in oxidative stress and poor osteogenesis in the peri ...
Jiajia Zhang, Ya-nan Wang, Tingting Jia, Haiyun Huang, Dongjiao Zhang, Xin Xu   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Biomimetic nanocomposite hydrogels for cartilage regeneration

, 2016
This chapter discusses current advancements in cartilage tissue regeneration with emphasis on the use of hydrogel-based nanocomposites for improved cartilage regeneration.
Zhang, L.G., Castro, N.J., L.G. Zhang, N.J. Castro   +3 more
core   +1 more source

Optimization of structural and mechanical properties of electro-spun biodegradable scaffolds for vascular vissue regeneration [PDF]

, 2013
Includes abstract.Includes bibliographical references.Current replacements for diseased arteries include autologous and artificial grafts. The availability of autologous grafts is limited and artificial grafts tend to fail when applied to small calibre ...
Khatib, Rodaina Omar
core   +1 more source

Synergistic protective and regenerative effects of hyaluronic acid and polynucleotides against UVA-induced oxidative stress in dermal fibroblasts

Scientific Reports
Ultraviolet A (UVA) radiation, a principal driver of skin photoaging, generates excessive reactive oxygen species (ROS) in dermal fibroblasts, causing oxidative stress, loss of viability, inflammatory signaling, and extracellular matrix (ECM) degradation.
Trang Thanh Thien Tran, Soon Chul Heo, Jun Hee Lee, Hae-Won Kim   +3 more
doaj   +1 more source

A high-glucose diet affects Achilles tendon healing in rats

Scientific Reports, 2017
Chronic and acute tendinopathies are difficult to treat and tendon healing is generally a very slow and incomplete process and our general understanding of tendon biology and regeneration lags behind that of muscle or bone.
Stefanie Korntner, Nadja Kunkel, Christine Lehner, Renate Gehwolf, Andrea Wagner, Peter Augat, Daniel Stephan, Verena Heu, Hans-Christian Bauer, Andreas Traweger, Herbert Tempfer   +10 more
doaj   +1 more source

An in situ tissue engineering scaffold with growth factors combining angiogenesis and osteoimmunomodulatory functions for advanced periodontal bone regeneration

Journal of Nanobiotechnology, 2021
Background The regeneration of periodontal bone defect remains a vital clinical challenge. To date, numerous biomaterials have been applied in this field. However, the immune response and vascularity in defect areas may be key factors that are overlooked
Tian Ding, Wenyan Kang, Jianhua Li, Lu Yu, Shaohua Ge   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source