Results 71 to 80 of about 2,574,116 (304)
Emerging cardiovascular risks of micro- and nanoplastics: toxic effects and mechanistic pathways
Particle and Fibre ToxicologyMicro- and nanoplastics (MNPs), due to their widespread distribution and chemical stability, have emerged as novel environmental contaminants threatening cardiovascular health.
Gang Liu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Craniofacial Bone Regeneration using iPS Cell-Derived Neural Crest Like Cells [PDF]
, 2018 Induced pluripotent stem (iPS) cells represent a powerful source for cell-based tissue regeneration because they are patient-specific cells and can differentiate into specialized cell types. Previously, we have demonstrated the derivation of neural crest
정한성
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The selection and application of design methodologies for the design of bone tissue scaffolds [PDF]
, 2013 Research motivation: Bone tissue scaffolds offer a way forward in a strategy to change from tissue replacement to tissue regeneration. Bone tissue scaffolds are a combination of a physical construct, with clearly defined three-dimensional spatial ...
Blogg, Ken
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Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Tissue Engineering for Peripheral Nerve Regeneration
, 2010 The outcome of peripheral nerve repair has changed very little over the past 50 years, and clinical outcomes remain generally poor. Surgical technique has evolved to a high level of technical microsurgical proficiency, but this approach remains unable to
Giorgio Terenghi +5 more
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Journal of Orthopaedic Surgery and Research, 2023 Background Mesenchymal stem cells (MSCs)-based therapy offers an effective strategy for bone regeneration to solve the clinical orthopedic problems. However, the transcriptional regulation of multiple transitional stages of continuous osteogenesis from ...
Xiao Ru +5 more
doaj +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Tissue regeneration in porous structures for bone engineering applications
, 2013 Scaffold design for bone regeneration is currently widely investigated as pore architecture can dramatically impact tissue formation in porous biomaterials used in regenerative medicine. A wide variety of 3D structures is used for this purpose, which has
Knychala, J.
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