Results 81 to 90 of about 2,574,116 (304)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Nanotechnology in osteochondral regeneration

, 2014
With the development of nanotechnology, a better understanding of the role of feature size (nano, micro, and macro) on cell and tissue behavior, and a focused effort of regenerative medicine and tissue engineering (TE) research on mimicking native tissue
Zhang, L.G., O'Brien, J.R., Castro, N.J.
core   +1 more source

FAK-mediated mechanotransduction in skeletal regeneration [PDF]

, 2007
The majority of cells are equipped to detect and decipher physical stimuli, and then react to these stimuli in a cell type-specific manner. Ultimately, these cellular behaviors are synchronized to produce a tissue response, but how this is achieved ...
Kim Jae-Beom, Jill A Helms, Jennifer A Currey, Leucht Philipp, Helms, Jill A., Kim, Jae-Beom, Jae-Beom Kim, Leucht, Philipp, Currey Jennifer A., Brunski John, Helms Jill A., Currey, Jennifer A., Philipp Leucht, Brunski, John, John Brunski   +14 more
core   +2 more sources

Proceedings of the Conference on Progress in Electrically Active Implants - Tissue and Functional Regeneration (ELAINE 2020) [PDF]

, 2020
The conference on Progress in Electrically Active Implants - Tissue and Functional Regeneration (ELAINE 2020) focused on novel methods in the electric stimulation of bio-material compounds of living cells and implantable electric stimulation devices ...

core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism

Scientific Reports
Oral cancer stands as a prevalent maligancy worldwide; however, its therapeutic potential is limited by undesired effects and complications. As a medicinal edible fungus, Chaga mushroom (Inonotus obliquus) exhibits anticancer effects across diverse ...
Donghyeon Yeo, Yeo Gyun Yun, Seong-Jin Shin, Khandmaa Dashnyam, Anand Khurelbaatar, Jun Hee Lee, Hae-Won Kim   +6 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Regulation of cardiac fibroblasts reprogramming into cardiomyocyte‐like cells with a cocktail of small molecule compounds

FEBS Open Bio
Myocardial infarction results in extensive cardiomyocyte apoptosis, leading to the formation of noncontractile scar tissue. Given the limited regenerative capacity of adult mammalian cardiomyocytes, direct reprogramming of cardiac fibroblasts (CFs) into ...
Danyang Chang, Changye Sun, Xiangqin Tian, Hongyin Liu, Yangyang Jia, Zhikun Guo   +5 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Vascular tissue engineering: pathological considerations, mechanisms, and translational implications

, 2019
Clinical translation of vascular tissue engineering is hampered by inconsistencies in graft outcomes. In this chapter, we argue that variation in graft outcomes is largely due to our lack of fully understanding vascular regeneration and remodeling in ...
Rotmans, Joris, Zilla, Peter, Schoen, Fred, Walpoth, Beat, Bowlin, Gary, Bergmeister, Helga, Fioretta, Emanuela S., Smits, Anthal I.P.M., Kong, Deling, Bouten, Carlijn V.C., Klouda, E.L. (Leda), Mallone, Anna   +11 more
core   +1 more source