Results 41 to 50 of about 4,666,864 (263)

Fertility preservation for girls and young women with cancer: population-based validation of criteria for ovarian tissue cryopreservation [PDF]

, 2014
Background: Ovarian tissue cryopreservation with later reimplantation has been shown to preserve fertility in adult women, but this approach remains unproven and experimental in children and adolescents.
Edgar, Angela E, Anderson, Richard A, Wallace, W Hamish B, Smith, Alice Grove, Kelsey, Thomas W   +4 more
core   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Doxorubicin/Adriamycin Monotherapy or Plus Ifosfamide in First-Line Treatment for Advanced Soft Tissue Sarcoma: A Pooled Analysis of Randomized Trials

Frontiers in Oncology, 2021
BackgroundDoxorubicin/Adriamycin (ADM) alone or combined with ifosfamide (IFO) (AI) is available for previously untreated advanced soft tissue sarcoma (ASTS). However, the clinical choice between them remains controversial.
Bi-Cheng Wang, Bo-Hua Kuang, Bo-Ya Xiao, Bo-Ya Xiao, Guo-He Lin   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

p38 MAPK orchestrates cross-tissue potassium homeostasis for survival

Nature Communications
Potassium is vital for life, yet how potassium homeostasis is maintained at the tissue or organismal level under dietary scarcity remains poorly understood.
Rong Huang, Fangchao Hu, Yiyao Li, Qifei Gao, Jintao Huang, Jiarui Wang, Wei Lu, Liping Wang, Yapeng Fang, T. Keith Blackwell, Ziyun Wu   +10 more
doaj   +1 more source

Expression of asparagine synthetase and its clinical significance in colorectal cancer tissue [PDF]

精准医学杂志
Objective To investigate the expression of asparagine synthetase (ASNS) in colorectal cancer (CRC) and its association with the clinicopathological features and prognosis of patients.
YAO Yifan, LI Na, RAN Wenwen, ZHAO Han, XING Xiaoming
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Overcoming skin rejection in composite tissue allotransplantation [PDF]

, 2008
The application of composite tissue techniques is constrained by the susceptibility of skin to rejection. The aim of this thesis is to improve our understanding of skin rejection and find ways to avoid it, in order to enable expansion of the ...
Horner, B., Horner, R.
core  

The importance of internal strain as opposed to interface pressure in the prevention of pressure related deep tissue injury

, 2010
For pressure ulcer prevention an ambitious goal would be the establishment of a mechanical threshold for tissue damage. In the past, several researchers have sought to establish such a threshold often involving the loading time.
Oomens, CWJ Cees, Bader, D.L., Loerakker, S Sandra, Loerakker, S., Oomens, C.W.J., Bader, DL Dan, Loerakker, Sandra   +6 more
core   +1 more source