Results 41 to 50 of about 2,241,494 (303)

A taxonomy of epithelial human cancer and their metastases [PDF]

, 2009
Background: Microarray technology has allowed to molecularly characterize many different cancer sites. This technology has the potential to individualize therapy and to discover new drug targets.
Olivier Gevaert, Anneleen Daemen, Bart De Moor, Louis Libbrecht, CH Chung, TR Golub, B Weigelt, T Sorlie, DN Hayes, CM Perou, A Bhattacharjee, A Alizadeh, T Sorlie, S Ramaswamy, TJ Giordano, D Rhodes, S Ramaswamy, GV Glinsky, N Pavlidis, RW Tothill, RA Bender, G Bloom, XJ Ma, D Talantov, CL Wilson, M Dai, A Subramanian, G Dennis, DW Huang, PS Nelson, M Cuatrecasas, JH Eichhorn, SK Tickoo, G Ayala, J Brugarolas, P Staller, X Liu, BJ Yoder, M Lacroix, B Weigelt, C Sotiriou, EA Rakha, C Sotiriou, AV Ivshina, M Ignatiadis, JX Yu, Z Hu, EK Sloan, AK Witkiewicz, L Lukes, AK Witkiewicz, XJ Ma, K Pavlakis, S Troup, K Wennmalm, P Schedin, G Finak, KA Oien, HG Laberke, MB Amin, SJ Jung, RC Bast Jr, JD Seidman, H Kang, H Naora, SM Smorenburg, T Sukata, IJ Matouk, S Khambata-Ford, MA Pantaleo, DH Ki, A Ramasamy, M Snyder, J Belmont, K Chin, LD Miller, J Pittman   +76 more
core   +3 more sources

Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis. [PDF]

, 2020
There are limited treatment options for immunosuppressed patients with lethal invasive fungal infections due to Fusarium and Scedosporium Manogepix (MGX; APX001A) is a novel antifungal that targets the conserved Gwt1 enzyme required for localization of ...
Alkhazraji, Sondus, Alqarihi, Abdullah, Gebremariam, Teclegiorgis, Gu, Yiyou, Ibrahim, Ashraf S, Mamouei, Zeinab, Shaw, Karen J, Singh, Shakti, Wiederhold, Nathan P   +8 more
core   +1 more source

Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study [PDF]

, 2019
BACKGROUND: For virtually every patient with colorectal cancer (CRC), hematoxylin-eosin (HE)-stained tissue slides are available. These images contain quantitative information, which is not routinely used to objectively extract prognostic biomarkers.
Brenner, H., Chang-Claude, J., Charoentong, P., Ferber, D., Gaiser, T., Halama, N., Herpel, E., Hoffmeister, M., Jansen, L., Jäger, D., Kather, J. N., Krisam, J., Luedde, T., Marx, A., Reyes-Aldasoro, C. C., Valous, N. A., Weis, C. A., Zörnig, I.   +17 more
core   +2 more sources

A Nonparametric Method for the Derivation of α/β Ratios from the Effect of Fractionated Irradiations [PDF]

, 1991
Multifractionation isoeffect data are commonly analysed under the assumption that cell survival determines the observed tissue or tumour response, and that it follows a linear-quadratic dose dependence.
A.M. Kellerer, D. Chmelevsky, Douglas B.G., Douglas B.G., Efron B, Efron B, Guttenberger R., Han A.K, Henkelman R.M., J. Kummermehr, Kellerer A.M., Kummermehr J., Lam G.K.Y., Maciejewski B., R. Guttenberger, Taylor J.M.G., Thames H.D, Tucker S.L, Vegesna V., Williams M.V.   +19 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

IMPACTS OF TISSUE-TYPE PLASMINOGEN ACTIVATOR (TPA) ON NEURONAL SURVIVAL

Frontiers in Cellular Neuroscience, 2015
Tissue-type plasminogen activator (tPA) a serine protease is constituted of five functional domains through which it interacts with different substrates, binding proteins and receptors.
Arnaud eChevilley, Flavie eLesept, Sophie eLenoir, Carine eAli, Jérôme eParcq, Denis eVivien   +5 more
doaj   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Ifosfamide with regional hyperthermia in soft-tissue sarcomas [PDF]

, 2003
For high-risk soft tissue sarcomas (HR-STS) of adults, new treatment strategies are needed to improve outcome with regard to local control and overall survival.
Issels, Rolf-Dieter, Schlemmer, M., Wendtner, Clemens-Martin   +2 more
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

The microbiome types of colorectal tissue are potentially associated with the prognosis of patients with colorectal cancer

Frontiers in Microbiology, 2023
As the second leading cause of cancer worldwide, colorectal cancer (CRC) is associated with a poor prognosis. Although recent studies have explored prognostic markers in patients with CRC, whether tissue microbes carry prognostic information remains ...
Yixin Xu, Jing Zhao, Yu Ma, Jia Liu, Yingying Cui, Yuqing Yuan, Chenxi Xiang, Dongshen Ma, Hui Liu, Hui Liu   +9 more
doaj   +1 more source