Results 51 to 60 of about 4,666,864 (263)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma

World Journal of Surgical Oncology, 2018
Background Retroperitoneal soft tissue sarcomas (STS) include a number of histologies but are rare, with approximately 3000 cases in the USA per year. Retroperitoneal STS have a high incidence of local and distant recurrence.
Michael J Nathenson, Constance M Barysauskas, Robert A Nathenson, William F Regine, Nader Hanna, Edward Sausville   +5 more
doaj   +1 more source

Postnatal development of depth-dependent collagen density in ovine articular cartilage [PDF]

, 2010
Articular cartilage (AC) is the layer of tissue that covers the articulating ends of the bones in diarthrodial joints. Adult AC is characterised by a depth-dependent composition and structure of the extracellular matrix that results in depth-dependent ...
Kranenbarg, S., Leeuwen, J.L., van, Barend van Lagen, Turnhout, van, M.C.; id_orcid, Han Zuilhof, van Leeuwen, J.L., Turnhout, van, M.C., Turnhout, M.C., van, van Lagen, B., Henk Schipper, van Turnhout, M.C., Schipper, H., Leeuwen, van, J.L., Turnhout, MC Mark van, Lagen, van, B., Schipper, H, Leeuwen, JL Johan van, Lagen, B., van, Zuilhof, Han, Zuilhof, H., Mark C van Turnhout, Sander Kranenbarg, Lagen, B van, Kranenbarg, S, Johan L van Leeuwen   +24 more
core   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reduced RVSWI Is Associated With Increased Mortality in Connective Tissue Disease Associated Pulmonary Arterial Hypertension

Frontiers in Cardiovascular Medicine, 2020
Rationale: The prognosis of pulmonary arterial hypertension is poor, especially amongst patients with connective tissue disease related pulmonary arterial hypertension.
Katharine R. Clapham, Kristin B. Highland, Youlan Rao, Wassim H. Fares   +3 more
doaj   +1 more source

Effects of mycorrhizal fungi and Pseudomonas fluorescens Bacteria on the growth and survival of Ribes khorasanicum Saghafi & Assadi tissue culture plantlets [PDF]

تحقیقات جنگل و صنوبر ایران, 2016
Ribes khorasanicum Saghafi & Assadi is considered as one of the valuable medicinal native species of Razavi Khorasan province that is distributed across high-altitudes of Hezar Masjed Mountains in a small range of Dargaz and Kalat cities as scattered ...
Hadi Darroudi, Abbas Safarnejad, Moslem Akbarinia, Seyyed Mohsen Hosseini, Mohammad Hajian Shahri   +4 more
doaj   +1 more source

Cancer Survival Group: UK Life Tables

, 2012
Life tables constructed by the Cancer Survival Group for use in survival analyses covering England, Wales, Scotland, and Northern Ireland between 1971 and 2009.
Cancer Survival Group,, Cancer Survival Group   +1 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source