By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Hematopoietic (stem) cells—The elixir of life?
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma
Background Retroperitoneal soft tissue sarcomas (STS) include a number of histologies but are rare, with approximately 3000 cases in the USA per year. Retroperitoneal STS have a high incidence of local and distant recurrence.
Michael J Nathenson +5 more
doaj +1 more source
Comparison of various lazaroid compounds for protection against ischemic liver injury [PDF]
Lazaroids are a group of 21-aminosteroids that lack steroid action but have a potent cytoprotective effect by inhibiting iron-dependent lipid peroxidation.
Ishizaki, N +8 more
core +2 more sources
Prognostic factors for survival in soft tissue sarcoma [PDF]
Between 1975 and 1984, 125 cases of histologically confirmed soft tissue sarcomata (STS) were registered in the Department of Clinical Oncology in Edinburgh. Of these, 100 were eligible for analysis of prognostic factors. The overall 5-year survival rate was 21.5%. Univariate analysis demonstrated that extent of surgery, radical versus palliative or no
J N, el-Jabbour +6 more
openaire +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Effects of mycorrhizal fungi and Pseudomonas fluorescens Bacteria on the growth and survival of Ribes khorasanicum Saghafi & Assadi tissue culture plantlets [PDF]
Ribes khorasanicum Saghafi & Assadi is considered as one of the valuable medicinal native species of Razavi Khorasan province that is distributed across high-altitudes of Hezar Masjed Mountains in a small range of Dargaz and Kalat cities as scattered ...
Hadi Darroudi +4 more
doaj +1 more source
Cannabinoid receptor CB2 drives HER2 pro-oncogenic signaling in breast cancer [PDF]
Pharmacological activation of cannabinoid receptors elicits antitumoral responses in different models of cancer. However, the biological role of these receptors in tumor physio-pathology is still unknown.
Alkatout, Ibrahim +31 more
core +1 more source
The role and implications of mammalian cellular circadian entrainment
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Volumetric assessment of breasts in patients undergoing fat grafting with pre-operative expansion (BRAVA®): experience of Santa Casa de São Paulo [PDF]
INTRODUCTION: Autologous fat graft possesses the desired qualities of a filling material. However, the largest barriers to its further development are unpredictable results and high rate of absorption of the grafted fat over time.
Murillo Francisco Pires Fraga +3 more
doaj +1 more source

