Results 41 to 50 of about 421,672 (303)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Transplant arteriosclerosis : an experimental study on risk factors and pathogenetic mechanisms [PDF]

, 2001
In this thesis, we focused on vascular damage inflicted after transplantation, i.e. injury of the graft vasculature as a result of an alloreactive response of the host against the graft, and everal factors in-fluencing this process.
Hillebrands, Jan Lucas, Hillebrands, Jan Lucas,, Hillebrands, Jan Lucas; id_orcid   +2 more
core  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal evolution of early innate immune responses triggered by neural stem cell grafting [PDF]

, 2012
INTRODUCTION: Transplantation of neural stem cells (NSCs) is increasingly suggested to become part of future therapeutic approaches to improve functional outcome of various central nervous system disorders. However, recently it has become clear that only
Van Der Linden, Anne-Marie, Van der Linden, Annemie, Herman Goossens, Annemie Van der Linden, Berneman, Zwi Nisan, De Vocht, Nathalie, Debbie Le Blon, Hoornaert, Chloé, Kristien Reekmans, Berneman, Zwi, Jasmijn Daans, Reekmans, Kristien, Nathalie De Vocht, Ponsaerts, Peter, Fransen, Erik, Chloé Hoornaert, Hoornaert, Chlo\ue9, Erik Fransen, Praet, Jelle, Le Blon, Debbie, Zwi Berneman, Goossens, Herman, Peter Ponsaerts, Jelle Praet, Daans, Jasmijn   +24 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Long non‐coding RNA VAL facilitates PKM2 enzymatic activity to promote glycolysis and malignancy of gastric cancer

Clinical and Translational Medicine, 2022
Background Gastric cancer (GC) is one of the most common types of cancer worldwide, which leads to more than 10% of cancer‐related deaths. Metabolism reprogramming presents as a pivotal event in cancer initiation and progression through enhancing aerobic
Ting Dai, Xin Zhang, Xiang Zhou, Xiaoxia Hu, Xiaodi Huang, Feiyue Xing, Han Tian, Yun Li   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Fetal Liver Cell Transplantation

, 2012
Fetal liver cell transplantation is a promising technique and is entering its clinical application phase. Temporary support of liver function is clearly obtained, and short-term benefit can be achieved for patients.
Suchitra Sumitran-Holgersson, Meghnad Joshi, Michael Olausson, Sumitran-Holgersson, Suchitra,, Olausson, Michael,, Joshi, Meghnad,   +5 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Islets of Langerhans Are Protected from Inflammatory Cell Recruitment during Reperfusion of Rat Pancreas Grafts [PDF]

, 2010
Background: Ischemia/reperfusion (I/R) injury plays a pivotal role in the development of graft pancreatitis, with ischemia time representing one of its crucial factors.
Winter, H., Waldner, H., Löhe, F., Eichhorn, M. E., Massberg, S., Preissler, G., Messmer, K.   +6 more
core   +1 more source