Results 61 to 70 of about 421,672 (303)

Eligible DBD Donors Proceeding via the DCD Pathway: Incidence, Cause, and Outcomes in the United Kingdom

Transplantation Direct
Background. Eligible donation after brain death (DBD) donors may rarely proceed via the donation after circulatory death (DCD) pathway. The incidence, reasons for pathway divergence, and graft and recipient outcomes in the United Kingdom of this cohort ...
Mark Burgess, MBChB, MSc, FRCA, FFICM, MRCP, Laura Silsby, BSc, Susanna Madden, MSc, Joana Da Silva Letra, RN, Stephanie Thomson, Diploma in Nursing, Janine Tate, BSc, Diploma in Intensive Care, Sharon Mitchinson, Diploma in Nursing, Katherine Hurley, BSc, Rebecca Hurley, BSc, Marco Bon, Diploma in Nursing, Rachel Pritchard, BSc, Sue Duncalf, BSc, Dale Gardiner, MBBS, MBioEth, FFICM   +12 more
doaj   +1 more source

Hand Transplantation: Current concepts and management algorithm

Revista de la Facultad de Medicina, 2017
Introduction: Hand transplantation was first reported in 1964, and is currently one of the challenges that the 21st century poses to Medicine. Several related studies and advances have been achieved, thus allowing to explore new alternatives for patient ...
Carlos Ivan Carrillo-Moreno, Diana Paola Escobar-Serna, Samuel de Jesús González-Vélez, Eyner Lozano-Marquez   +3 more
doaj   +1 more source

Microsurgical composite tissue transplantation

The American Journal of Surgery, 1977
Since 1974, 69 patients with extensive defects have undergone reconstruction by microsurgical composite tissue transplantation. Using this method, donor composite tissue is isolated on its blood supply, removed to a distant recipient site, and the continuity of blood flow re-established by microvascular anastomoses.
D, Serafin, N G, Georgiade
openaire   +3 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The use of cadaver tissues in transplantation

Transplantation, 1964
IN the short span of thirteen years human-kidney homotransplantation has progressed from developmental uncertainty to a therapeutic endeavor that has rehabilitated many patients in terminal renal failure, both in this country and abroad. Contrary to many apprehensions, the use of drugs to suppress the immune response to homografts has not been ...
N P, COUCH, W J, CURRAN, F D, MOORE
openaire   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Knowledge and Attitudes Toward Organ/Tissue Donation and Transplantation Among Health Care Professionals Working in Organ Transplantation or Dialysis Units

, 2011
Objective. To evaluate the awareness and attitudes of health care professionals toward organ/tissue donation and transplantation. Methods. We included 309 health care professionals from 27 dialysis centers and eight organ transplantation centers in ...

core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source