Results 151 to 160 of about 413,621 (336)

Titer Antibodi Ayam Petelur Pascavaksinasi Avian Influenza Pada Peternakan Komersial Di Desa Denbantas, Kecamatan Tabanan

open access: yesIndonesia Medicus Veterinus, 2018
Penelitian ini bertujuan untuk mengetahui respon imun sekunder pascavaksinasi kedua AI pada peternakan komersial di Desa Denbantas, Kecamatan Tabanan. Sampel penelitian dipilih secara acak terhadap 10 ekor ayam petelur dari total 200 ekor. Sampel diambil
Zatya Wira Bhakty   +2 more
doaj  

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

open access: yesAdvanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu   +7 more
wiley   +1 more source

Efficient influenza A virus production in high cell density using the novel porcine suspension cell line PBG.PK2.1 [PDF]

open access: yes, 2019
Coronel, J.   +9 more
core   +1 more source

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

open access: yesAdvanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu   +8 more
wiley   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

open access: yesAdvanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei   +15 more
wiley   +1 more source

Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model

open access: yesAdvanced Science, EarlyView.
This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du   +13 more
wiley   +1 more source

CO36 | Inhibitor titer at diagnosis and clinical course in acquired hemophilia A: a single-center experience

open access: yesBleeding, Thrombosis and Vascular Biology
Background and Aims: Acquired hemophilia A (AHA) is a rare autoimmune bleeding disorder caused by neutralizing autoantibodies against factor VIII (FVIII).
doaj   +1 more source

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