Results 171 to 180 of about 438,789 (339)

EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways

open access: yesAdvanced Science, EarlyView.
EFTUD2, a spliceosomal GTPase linked to MFDM, regulates cortical development through apoptotic control. Conditional Eftud2 knockout in murine neural stem cells induces microcephaly and cortical disorganization, while pathogenic variants drive neuronal loss.
Liping Chen   +12 more
wiley   +1 more source

The impact of pathogen reduction on ABO isoagglutinin titers in apheresis platelets. [PDF]

open access: yesHematol Transfus Cell Ther
Yeghiazaryan M   +5 more
europepmc   +1 more source

High‐Throughput Tiling of Essential mRNAs Increases Potency of Antisense Antibiotics

open access: yesAdvanced Science, EarlyView.
The systematic tiling of essential genes’ mRNA here presented, proposes a valuable tool for the identification of novel PNA sequences with antibiotic potential. The high‐throughput synthetic set up opens the door to investigating thousands of sequences in an economic way and ultimately identifies potent antisense oligonucleotides while also giving room
Giorgia Danti   +3 more
wiley   +1 more source

Perfusion process with tangential flow filtration for oncolytic VSV-GP production. [PDF]

open access: yesFront Bioeng Biotechnol
Hamusics O   +7 more
europepmc   +1 more source

High‐Throughput MicroED for Probing Ion Channel Dynamics

open access: yesAdvanced Science, EarlyView.
High‐throughput MicroED offers a new approach for visualizing ion channel dynamics. This approach reveals NaK’s sodium binding modes and NaK2CNG’s potassium‐induced selectivity filter dilation and gating. By capturing these distinct structures, this work challenges traditional models of ion channel permeation and selectivity. Abstract Ion channels play
Marc J Gallenito   +4 more
wiley   +1 more source

Bayesian optimization and machine learning for vaccine formulation development. [PDF]

open access: yesPLoS One
Li L   +5 more
europepmc   +1 more source

Trypstatin as a Novel TMPRSS2 Inhibitor with Broad‐Spectrum Efficacy against Corona and Influenza Viruses

open access: yesAdvanced Science, EarlyView.
Trypstatin, a 61‐amino acid Kunitz‐type protease inhibitor derived from human Bikunin, potently inhibits TMPRSS2 and related proteases. It blocks spike‐ and hemagglutinin‐mediated entry of multiple respiratory viruses in vitro reduces SARS‐CoV‐2 replication in human airway cultures, and lowers viral load and symptoms in infected hamsters, demonstrating
Jan Lawrenz   +24 more
wiley   +1 more source

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