Results 191 to 200 of about 413,621 (336)
Advanced Science, EarlyView.This study reveals that the glycolytic enzyme HK2 mediates hypoxia‐induced astrocytic exosome biogenesis by directly phosphorylating nSMase1. These astrocytic exosomes impair brain endothelial tight junctions. Astrocyte‐specific knockdown of HK2 reduces exosome release and alleviates brain injury after MCAO.
Chen Chen +12 more
wiley +1 more source
Engineering <i>Yarrowia lipolytica</i> for high-level β-elemene production via combinatorial metabolic strategies. [PDF]
Synth Syst BiotechnolDai M +7 more
europepmc +1 more source
Generalized Tits system (Bruhat decompostition) on 𝑝-adic semisimple groups [PDF]
, 1966 Nagayoshi Iwahori
openalex +1 more source
Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis
Advanced Science, EarlyView.Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu +17 more
wiley +1 more source
High Cell Density Perfusion Process of Quail Cells Producing Oncolytic rVSV-NDV. [PDF]
Eng Life SciJacobtorweihe L +5 more
europepmc +1 more source
Advanced Science, EarlyView.This study extensively characterizes the B cell response of rainbow trout (Oncorhynchus mykiss) in response to red mark syndrome (RMS). This disease, suspected to be caused by a Midichloria‐like organism (MLO), induces skin lesions in the infected animals, characterized by a massive influx of IgM+ B cells.
J Germán Herranz‐Jusdado +10 more
wiley +1 more source