Results 241 to 250 of about 598,693 (386)

Reprogramming of Fatty Acid Metabolism via PPARα‐Orchestrated FADS2 in Keratinocytes Modulates Skin Inflammation in Psoriasis

Advanced Science, EarlyView.
This study identifies fatty acid desaturase 2 (FADS2) as a key regulator linking polyunsaturated fatty acid (PUFA) metabolism to psoriatic inflammation. FADS2 deficiency impairs docosahexaenoic acid (DHA) biosynthesis, enhances NF‐κB signaling, and promotes neutrophil‐driven skin inflammation. PPARα transcriptionally activates FADS2, and its activation
Jiangluyi Cai, Xue Zhou, Yu Zhuang, Lian Cui, Rui Ma, Youdong Chen, Nan Yang, Qianyu Chen, Yuanyuan Wang, Peiyao Zhu, Lingling Yao, Qian Yu, Xiaomin She, Xuyang Zhou, Yuemeng Huang, Zengyang Yu, Xilin Zhang, Jiajing Lu, Yuling Shi, Chunyuan Guo   +19 more
wiley   +1 more source

High rate of seroeligibility among <i>MYBPC3</i>-associated hypertrophic cardiomyopathy patients for TN-201, an adeno-associated virus serotype 9 <i>MYBPC3</i> gene therapy. [PDF]

Front Med (Lausanne)
Desai MY, Massera D, Wang H, Wong TC, Wever-Pinzon O, Lakdawala NK, Giudicessi JR, Abraham T, Nagueh S, Rader F, Masri A, Turer E, Mushonga P, Flores EB, Harrison W, Sonicheva-Paterson N, Argast G.   +16 more
europepmc   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, EarlyView.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source

Co-utilization of corncob hydrolysate and fermentation wastewater for eicosapentaenoic acid production by Schizochytrium sp. [PDF]

Biotechnol Biofuels Bioprod
Ou Y, Qin Y, Wang Y, Liu J, Yang H, Zhu X.   +5 more
europepmc   +1 more source

Pigment Epithelium‐Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT‐1

Advanced Science, EarlyView.
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi, Qi‐Long Tang, Jin‐Hong Wang, Yan‐Lan Long, Sai‐Feng Zhao, Zhen Zhao, Wan‐Ting Xie, Zi‐Ming Li, Hao‐Ming Lu, Tian‐Xiao Gao, Zhen‐Zhen Fang, Ti Zhou, Bo‐Xing Li, Xia Yang, Guo‐Quan Gao, Wei‐Wei Qi   +15 more
wiley   +1 more source

Immunoadsorption as a Rescue Therapy for Very High Anti-B Titer in ABO-Incompatible Kidney Transplantation. [PDF]

Am J Case Rep
Rakpithayanon C, Mai-On N, Konwai S, Wuttiputhanun T, Townamchai N, Sutherasan M, Opanuraks J, Avihingsanon Y, Udomkarnjananun S.   +8 more
europepmc   +1 more source

On the Agglutinin Titers of Normal Human Sera. II

, 1955
Tanemoto FURUHATA, Takeo Iida, Toshiyuki Seki, Masashi HORIUCHI, Hisashi HASEBE, Tadaho MURAO   +5 more
openalex   +2 more sources

0105 Serum and colostrum antibody titers in Holstein cows, and the relationship between these titers and serum antibody titers in their calves

Journal of Animal Science, 2016
David J. Hurley, L.O. Ely, J. D. Chapman, Amelia R. Woolums, Derek J. McLean   +4 more
openaire   +3 more sources

Citrullination of AKT2 Catalyzed by PAD1 Facilitates the Maintenance of Stemness Characteristics of Ovarian Cancer Stem‐Like Cells in Ovarian Cancer

Advanced Science, EarlyView.
PAD1 is upregulated within the CD133+ subset or cisplatin‐resistant ovarian cancer cells, which is positively associated with the upregulation of stemness‐related markers and maintenance of stemness in OCSLCs. Mechanistically, PAD1‐catalyzed AKT2 citrullination at R202 facilitates AKT2 phosphorylation, promoting CEBPβ expression and its binding to the ...
Teng Xue, Xiaoqiu Liu, Chao Song, Shujia Fei, Jian Gu, Yun Han, Jia Xing, Xiaohan Liu, Fei Liang, Paul R Thompson, Xuesen Zhang   +10 more
wiley   +1 more source

Effects of binary ethyleneimine and formaldehyde inactivation methods on foot-and-mouth disease virus vaccine immune responses and kinetics. [PDF]

Sci Rep
Habtewold WT, Welde N, Kenubih A, Getahun YA, Abayneh T, Getachew B, Woldemedhin W, Tesfaye Y, Tesfaw L, Getachew Y, Negussie H.   +10 more
europepmc   +1 more source